Enamel Matrix Proteins and Periodontal Wound Healing and Regeneration

Clinical Advances in Periodontics
Anton SculeanDieter D Bosshardt

Abstract

The goal of regenerative periodontal therapy is the reconstitution of lost periodontal structures (i.e., the new formation of root cementum, periodontal ligament, and alveolar bone). Results from preclinical and clinical research in the last decade have provided evidence on the biologic rationale and clinical applications of an enamel matrix derivative (EMD) protein in periodontal wound healing and regeneration. Case Presentations and Literature Overview: This paper will provide an overview of the biologic rationale for using enamel matrix proteins (EMPs) in regenerative periodontal therapy. Based on the available preclinical and clinical evidence, the main clinical indications for using EMD in regenerative periodontal therapy will be discussed. The available data provide evidence of the biologic rationale of EMPs to support periodontal wound healing and regeneration. The application of EMD in conjunction with a surgical access may result in substantial regeneration of root cementum, periodontal ligament, and bone, thus improving the clinical outcomes in intrabony, recession, and Class II furcation defects.

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Citations

Aug 20, 2014·International Journal of Endocrinology·Marjan NokhbehsaimJames Deschner
Apr 14, 2015·Periodontology 2000·Anton SculeanWilliam V Giannobile
Sep 13, 2014·Journal of Periodontology·Richard T KaoMark A Reynolds
Apr 14, 2015·Periodontology 2000·Anton SculeanAndreas Stavropoulos
Jul 16, 2015·Clinical Oral Investigations·Yufeng ZhangRichard J Miron
Dec 16, 2016·Journal of Clinical Periodontology·Yoshinori ShirakataAnton Sculean
Oct 2, 2017·Journal of Clinical Periodontology·Yoshinori ShirakataAnton Sculean
Jun 28, 2018·Clinical Oral Investigations·Isabela Lima França-GrohmannEnilson Antonio Sallum
Jul 24, 2014·Molecular Oral Microbiology·J DeschnerM Nokhbehsaim
Aug 15, 2014·Journal of Diabetes Research·Marjan NokhbehsaimJames Deschner
May 16, 2014·Journal of Periodontal Research·R GruberA Sculean
Aug 14, 2015·Clinical Oral Investigations·Yulan WangRichard J Miron
Nov 30, 2013·Mediators of Inflammation·Marjan NokhbehsaimJames Deschner
Dec 19, 2014·Clinical Oral Investigations·Richard J MironAnton Sculean
Feb 3, 2015·Clinical Oral Implants Research·Dieter D BosshardtHendrik Terheyden
Feb 26, 2016·Journal of Dental Research·D L CochranA Takemura
Jan 8, 2014·Clinical Implant Dentistry and Related Research·Shuang YangYufeng Zhang
Nov 30, 2011·Journal of Periodontology·Richard J MironAnton Sculean
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Oct 21, 2016·Clinical Oral Investigations·Richard J MironYufeng Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Benedikt EggersMarjan Nokhbehsaim

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