Enamel remineralization therapies for treating postorthodontic white-spot lesions: A systematic review

The Journal of the American Dental Association
Laura Fernández-FerrerCarlos Bellot-Arcís

Abstract

One of the adverse effects of orthodontic treatment is the appearance of white-spot lesions (WSLs) resulting from enamel demineralization. The objective of this systematic review was to investigate the effectiveness of remineralization therapies on WSLs after orthodontic treatment. In this systematic review, the authors identified relevant articles listed in 5 databases-PubMed, the Cochrane Library, Scopus, Embase, and Web of Science-by using a combination of search terms referring to orthodontics, demineralization, and treatment. Ten articles on the efficacy of WSL remineralization therapies met the inclusion criteria. Among the studies of remineralizing therapy, neither fluoride mouthrinses nor phosphopeptide toothpastes with or without fluoride had any positive effect in addition to oral hygiene maintenance with fluoride toothpaste. A 5% sodium fluoride varnish was the only therapy to show a statistically significant improvement compared with results in the control group. The authors found large variations in results among the studies reviewed because of the different methods used. None of the treatments was capable of remineralizing WSLs. A 5% sodium fluoride varnish could improve remineralization of WSLs.

Associated Clinical Trials

Citations

May 16, 2019·Cranio : the Journal of Craniomandibular Practice·Roger Solow
Apr 23, 2021·Dental Materials Journal·Keiki NakamuraTakashi Muramatsu
May 13, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Licia Pacheco TeixeiraJuliana Malacarne-Zanon
Aug 2, 2021·Trials·Danchen QinUNKNOWN Core Outcome Set for trials on the prevention and treatment of enamel White Spot Lesions (COS-WSL) group
Aug 10, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Yunlei WangUNKNOWN Core Outcome Set for trials on the prevention and treatment of enamel White Spot Lesions (COS-WSL) group

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