Enamel subsurface lesion remineralisation with casein phosphopeptide stabilised solutions of calcium, phosphate and fluoride

Caries Research
N J CochraneE C Reynolds

Abstract

Casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) and amorphous calcium fluoride phosphate (CPP-ACFP) solutions have been shown to remineralise enamel subsurface lesions. The aim of this study was to determine the effect of ion composition of CPP-ACP and CPP-ACFP solutions on enamel subsurface lesion remineralisation in vitro. CPP-bound and free calcium, phosphate and fluoride ion concentrations in the solutions were determined after ultrafiltration. The ion activities of the free ion species present were calculated using an iterative computational program. The mineral deposited in the subsurface lesions was analysed using transverse microradiography and electron microprobe. CPP was found to stabilise high concentrations of calcium, phosphate and fluoride ions at all pH values (7.0-4.5). Remineralisation of the subsurface lesions was observed at all pH values tested with a maximum at pH 5.5. The CPP-ACFP solutions produced greater remineralisation than the CPP-ACP solutions at pH 5.5 and below. The mineral formed in the subsurface lesions was consistent with hydroxyapatite and fluorapatite for remineralisation with CPP-ACP and CPP-ACFP, respectively. The activity gradient of the neutral ion pair CaHPO(4)(0)...Continue Reading

References

Jan 1, 1977·Caries Research·J M Cate, J Arends
Feb 28, 1978·Calcified Tissue Research·J L Meyer, E D Eanes
Jan 1, 1977·Caries Research·L M Silverstone
May 1, 1975·Archives of Oral Biology·E J Burke, E C Moreno
Nov 1, 1976·Journal of Dental Research·L G PeterssonG Frostell
Jan 1, 1991·Journal of Dental Research·J J Ten Bosch, B Angmar-Månsson
Sep 30, 1965·Annals of the New York Academy of Sciences·T KoulouridesW Pigman
Jan 1, 1968·The Journal of Physical Chemistry·A ChughtaiG H Nancollas
Sep 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Itaya, M Ui
Jun 1, 1984·Journal of Dental Research·J F de Rooij, G H Nancollas
Jan 1, 1981·Caries Research·J D FeatherstoneM W Smith
Jan 1, 1981·Archives of Oral Biology·J M BorggrevenF C Driessens
Oct 29, 1998·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·E C Reynolds
Feb 1, 1963·Journal of Ultrastructure Research·B ANGMARJ E GLAS
Jan 20, 2005·The Journal of Biological Chemistry·Keith J CrossEric C Reynolds
Jul 7, 2007·Journal of Dentistry·Christos Rahiotis, George Vougiouklakis
Jul 20, 2007·Journal of Oral Science·Maki OshiroMasashi Miyazaki
Jul 1, 1947·Journal of the American Chemical Society·H H BROENE, T DE VRIES
Jul 1, 1970·Journal of Research of the National Bureau of Standards. Section A, Physics and Chemistry·Thomas M GregoryWalter E Brown

❮ Previous
Next ❯

Citations

Jul 19, 2012·Journal of Dental Research·T SitthisettapongT Derouen
Apr 16, 2014·Archives of Oral Biology·Dusa VukosavljevicWalter L Siqueira
Apr 25, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Nathan J CochraneEric C Reynolds
Aug 25, 2009·Acta Odontologica Scandinavica·Veerasamy Yengopal, Steffen Mickenautsch
Jul 9, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yin-Lin WangChun-Pin Lin
Mar 5, 2013·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Hong ChenYin Ding
Jan 1, 2013·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Greg J HuangJack C Matunas
Dec 19, 2015·Archives of Oral Biology·Jackeline Gallo do AmaralMichele E Barbour
Oct 21, 2016·Clinical Oral Investigations·Danielle Mendes da CamaraAlberto Carlos Botazzo Delbem
Jun 7, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Roslyn J MayneEric C Reynolds
Dec 4, 2010·Journal of Dentistry·X WangA Lussi
Jul 15, 2009·Journal of Dentistry·Fan CaiEric C Reynolds
Aug 28, 2009·Australian Dental Journal·N J CochraneE C Reynolds
May 30, 2013·Australian Dental Journal·S Salanitri, W K Seow
Nov 29, 2012·Australian Dental Journal·D GurunathanSa Kumar
Oct 31, 2012·International Dental Journal·Jo E FrenckenEce Eden
Dec 8, 2010·Periodontology 2000·Jonas A RodriguesKlaus W Neuhaus
Jul 14, 2010·International Journal of Dental Hygiene·O MarchisioA Genovesi
Aug 29, 2012·Australian Dental Journal·N J CochraneE C Reynolds
Jan 1, 2014·European Journal of Oral Sciences·Masayuki KagaHidehiko Sano
Mar 13, 2015·Clinical Oral Investigations·Tamara PericVesna Tomic Spiric
Jul 30, 2016·Progress in Biomaterials·Sergey V Dorozhkin
Jan 23, 2015·Clinical Oral Investigations·Adelisa Rodolfo Ferreira TiveronDenise Pedrini
May 15, 2015·Clinical Oral Investigations·M M ManarelliJ P Pessan
Aug 25, 2015·Journal of Dentistry·J M ConceiçãoJ P Pessan
Jul 17, 2015·Microscopy Research and Technique·Mahtab MemarpourNaghmeh Sattarahmady
Mar 22, 2015·Clinical Oral Investigations·Luciene Pereira de CastroCélio Percinoto
Dec 18, 2013·Journal of Dentistry·Danielle Mendes da CamaraAlberto Carlos Botazzo Delbem
May 6, 2015·Journal of Dentistry·Marcelle DanelonAlberto Carlos Botazzo Delbem
Feb 27, 2013·Journal of Dentistry·I ZalizniakE C Reynolds
Apr 26, 2016·Journal of Dentistry·Samantha J ByrneEric C Reynolds
May 8, 2016·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·V GopalakrishnanA Itthagarun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.