Enantiomeric Excess Sensitivity to Below One Percent by Using Femtosecond Photoelectron Circular Dichroism

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Alexander KastnerThomas Baumert

Abstract

Photoelectron circular dichroism (PECD) is experimentally investigated with chiral specimens with varying amounts of enantiomeric excess (ee). As a prototype, we measure and analyze the photoelectron angular distribution from randomly oriented fenchone molecules in the gas phase that result from ionization with circularly polarized femtosecond laser pulses. The quantification of these measurements shows a linear dependence with respect to the ee values. In addition, differences in the ee values (denoted as detection limit) of below one percent can be distinguished for nearly enantiopure samples, as well as for almost racemates. In combination with the use of a reference, the assignment of absolute ee values is possible. The present measurement time is a few minutes, but this could be reduced. This table-top laser-based approach should facilitate widespread implementation in chiral analysis.

References

May 1, 2012·Chirality·Philipp HorschKarl-Michael Weitzel
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Jul 31, 2013·Physical Review Letters·David Patterson, John M Doyle
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Citations

Nov 4, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jörn LepelmeierUlrich Heiz
Dec 16, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Gustavo A GarciaIvan Powis
Jun 27, 2017·Physical Chemistry Chemical Physics : PCCP·Jörn LepelmeierAras Kartouzian
Dec 22, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Mohammad M Rafiee FanoodIvan Powis
Apr 12, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Alexander KastnerThomas Baumert
Jul 19, 2019·Chirality·Aras Kartouzian
Jul 10, 2019·Physical Review Letters·Alexander A MilnerIlya Sh Averbukh
Mar 28, 2020·Physical Chemistry Chemical Physics : PCCP·Alexander KastnerThomas Baumert
Aug 11, 2020·The Journal of Chemical Physics·Georg WestphalTim Schäfer
Jul 10, 2017·The Journal of Chemical Physics·David W ChandlerDavid H Parker
Feb 21, 2021·The Journal of Chemical Physics·Cem SaribalJochen Küpper
Jul 23, 2019·The Journal of Physical Chemistry. a·Kilian FehreMarkus Schöffler
Nov 16, 2021·Physical Chemistry Chemical Physics : PCCP·Valérie BlanchetBaptiste Fabre
Nov 19, 2021·The Journal of Physical Chemistry Letters·Dhirendra P SinghIvan Powis

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