Enantiomeric resolution of chiral pesticides by high-performance liquid chromatography

Journal of Agricultural and Food Chemistry
Peng WangZhiqiang Zhou

Abstract

Successful enantiomeric separation of 10 chiral pesticides by high-performance liquid chromatography (HPLC) using cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC) chiral stationary phase (CSP) was performed. The mobile phase was n-hexane modified by ethanol, propanol, 2-propanol (IPA), butanol, or isobutanol. The effects of mobile phase composition and column temperature on the separation were investigated. Baseline separation was obtained with ethofumesate, fluroxypyr-meptyl, malathion, benalaxyl, diclofop-methyl, methamidophos, vinclozolin, and lactofen, whereas near baseline separation was obtained with profenofos and acetochlor. Butanol was the best modifier for benalaxyl; isobutanol was the best modifier for lactofen, malathion, diclofop-methyl, and ethofumesate; and IPA was the best modifier for the other five. Better separations were not always at low temperature. The elution orders of the eluting enantiomers were determined by a circular dichroism (CD) detector. The quantitative analysis methods for the enantiomers of ethofumesate, benalaxyl, and diclofop-methyl were established. Validation parameters include linearity, precision, and limit of detection (LOD). The enantiomeric residual analysis procedures in soil and...Continue Reading

Citations

Oct 21, 2011·Chirality·Wenjian Lao, Jay Gan
Nov 3, 2011·Environmental Toxicology and Chemistry·Guilherme L EmerickGeorgino H DeOliveira
Jan 24, 2009·Chirality·Shanshan ZhouWeiping Liu
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping ZhangLin He
Jan 22, 2010·Journal of Agricultural and Food Chemistry·Jinling DiaoZhiqiang Zhou
Jun 11, 2009·Journal of Agricultural and Food Chemistry·Jinling DiaoZhiqiang Zhou
Mar 15, 2008·Journal of Agricultural and Food Chemistry·Vanesa Guillén-CaslaLuis María Polo-Díez

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