Enantioselective additions of copper acetylides to cyclic iminium and oxocarbenium ions

Beilstein Journal of Organic Chemistry
Jixin LiuMary P Watson

Abstract

The development of enantioselective, copper-catalyzed alkynylations of cyclic iminium and oxocarbenium ions is reviewed. The use of chiral copper-based catalysts has enabled high yields and enantioselectivites in the formation of nitrogen- and oxygen-containing heterocycles with α-stereogenic centers. This review highlights both the accomplishments and the future work needed in this important area.

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