Enantioselective analysis of albendazole sulfoxide in plasma using the chiral stationary phase

Chirality
F O PaiasPierina S Bonato

Abstract

We present a method for the enantioselective analysis of albendazole sulfoxide (ABZSO) in plasma for application in clinical pharmacokinetic studies. ABZSO enantiomers were separated on a 5-micron Chiralcel OB-H column (4.6 x 150 mm) using hexane:ethanol (93:7, v/v) as the mobile phase and fluorescence detection. ABZSO was extracted with chloroform:isopropanol (8:2, v/v) from 500-microliter aliquots of acidified plasma, with full drug recovery. The proposed method presented quantitation limits of 20 ng/ml for (-)ABZSO and 50 ng/ml for (+)ABZSO and was linear up to a concentration of 5,000 ng/ml of each enantiomer.

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Citations

Nov 20, 2012·Analytical and Bioanalytical Chemistry·Massimo Del BubbaLuciano Lepri
Jan 25, 2003·Journal of Biochemical and Biophysical Methods·M J del NozalJ J Jiménez
Jul 10, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·V L LanchoteP S Bonato
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pierina Sueli BonatoOsvaldo Massaiti Takayanagui
Jan 11, 2012·Journal of Pharmaceutical and Biomedical Analysis·Viviane Cangerana HilárioAnderson Rodrigo Moraes de Oliveira
Nov 16, 2011·Expert Opinion on Pharmacotherapy·Osvaldo Massaiti TakayanaguiVera Lucia Lanchote
Apr 28, 2005·Expert Review of Neurotherapeutics·Osvaldo Massaiti Takayanagui

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