Enantioselective Borylation of Aromatic C-H Bonds with Chiral Dinitrogen Ligands

Angewandte Chemie
Bo SuJohn F Hartwig

Abstract

The borylation of C-H bonds catalyzed by transition metals has been investigated extensively in the past two decades, but no iridium-catalyzed enantioselective borylation of C-H bonds has been reported. We report a set of iridium-catalyzed enantioselective borylations of aromatic C-H bonds. This reaction relies on a set of newly developed chiral quinolyl oxazoline ligands. This process proceeds under mild conditions with good to excellent enantioselectivity, and the borylated products can be converted to enantioenriched derivatives containing new C-O, C-C, C-Cl, or C-Br bonds.

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Jul 6, 2018·Chemical Communications : Chem Comm·Jompol ThongpaenOlivier Baslé
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Nov 17, 2021·Chemical Communications : Chem Comm·Chabush HaldarBuddhadeb Chattopadhyay

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