Enantioselective C-H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution

Angewandte Chemie
Kai-Jiong XiaoJin-Quan Yu

Abstract

Significant progress has been made in the past decade regarding the development of enantioselective C-H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope of enantioselective C-H activation reactions.

References

Sep 1, 1966·Journal of Medicinal Chemistry·J L SpencerR R Chauvette
Jun 10, 2004·Journal of the American Chemical Society·Reema K ThaljiRobert G Bergman
Jan 27, 2005·Journal of the American Chemical Society·Norie Momiyama, Hisashi Yamamoto
Jan 27, 2005·Journal of the American Chemical Society·Alexander T RadosevichF Dean Toste
Mar 3, 2005·Journal of the American Chemical Society·Seiji ShirakawaJames L Leighton
Feb 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shiue-Shien WengChien-Tien Chen
Apr 6, 2006·Journal of the American Chemical Society·Thomas C Maier, Gregory C Fu
Jun 22, 2006·Angewandte Chemie·Chungen LiangPhilippe Dauban
Jan 25, 2008·Nature·Huw M L Davies, James R Manning
Jun 28, 2008·Journal of the American Chemical Society·David N Zalatan, J Du Bois
Jul 22, 2008·Angewandte Chemie·Erika MilczekSimon Blakey
Sep 30, 2009·Chemical Reviews·Michael P DoyleLei Zhou
Dec 19, 2009·Journal of the American Chemical Society·Bing-Feng ShiJin-Quan Yu
Jun 24, 2010·Nature Chemistry·Shou-Fei ZhuQi-Lin Zhou
Aug 21, 2010·Angewandte Chemie·Alice RenaudatOlivier Baudoin
Sep 20, 2011·Chemical Communications : Chem Comm·Saithalavi AnasHenri B Kagan
Nov 9, 2011·Journal of the American Chemical Society·Masayuki WasaJin-Quan Yu
Feb 14, 2012·Journal of the American Chemical Society·Ryan D BaxterDonna G Blackmond
Mar 13, 2012·Chemistry : a European Journal·Nicolas MartinOlivier Baudoin
Jan 12, 2013·Journal of the American Chemical Society·Xiu-Fen ChengJin-Quan Yu
Oct 25, 2013·Journal of the American Chemical Society·Ling ChuJin-Quan Yu
Oct 29, 2013·Journal of the American Chemical Society·Pan WangYong Tang
Jan 15, 2014·Journal of the American Chemical Society·Gui-Juan ChengYun-Dong Wu
Mar 20, 2014·Chemical Communications : Chem Comm·Dieter EndersAndreas Rembiak

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Citations

Jun 2, 2016·Journal of the American Chemical Society·Kai-Jiong XiaoJin-Quan Yu
Jul 9, 2016·The Journal of Organic Chemistry·Kankanala Ramakrishna, Chinnappan Sivasankar
May 10, 2017·Accounts of Chemical Research·Yan-Na MaShang-Dong Yang
Aug 23, 2017·Chemical Communications : Chem Comm·Chunbing YuGuofu Zhong
Apr 30, 2020·Angewandte Chemie·Yan ZhangLutz Ackermann
Aug 25, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Cady Cirbes, Joseph M Tanski
Oct 11, 2020·Angewandte Chemie·Lucy A HarwoodJeremy Robertson
Apr 20, 2021·Organic & Biomolecular Chemistry· SumitUpendra Sharma

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