Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis

Angewandte Chemie
Meng WangPing Lu

Abstract

The enantioselective intramolecular α-arylation of cyclobutanones has been established by combining palladium and enamine catalyst systems. Two different enantioselective control strategies have been developed for cyclobutanone substrates bearing O- or N-tethered aryl bromides. Further synthetic applications are also reported.

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Citations

Sep 25, 2019·Angewandte Chemie·Jan Sietmann, Johannes M Wahl
Mar 27, 2019·Angewandte Chemie·Yu-Li SunLi-Wen Xu
Jun 8, 2021·Natural Products and Bioprospecting·Mei WangLi-Dong Shao

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