Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group

Chirality
Neila M CassianoQuezia B Cass

Abstract

This work reports the result of the enantioselective disposition of pantoprazole, omeprazole, and lansoprazole in a same group of Brazilian health subjects. Ten nongenotyped healthy subjects were used for this study. Each subject received a single oral dose of 80 mg of pantoprazole, 40 mg of omeprazole, and 30 mg of lansoprazole, and the plasma concentrations of the enantiomers were measured for 8 h postdose. For pantoprazole and omeprazole, among the 10 volunteers investigated, only one volunteer (Subject # 4) presented higher plasma concentrations of the (+)-enantiomer than those of (-)-enantiomer. Nevertheless, the area under the concentration-time curve of the (+)-lansoprazole was higher than those the (-)-lansoprazole for all subjects. The comparison of proton pump inhibitors' enantiomers disposition from a single group volunteer demonstrated that pantoprazole and omeprazole can be used to differentiate extensive from poor CYP2C19 metabolizer while lansoprazole cannot do it.

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Citations

Mar 26, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ana R RibeiroMaria E Tiritan
Aug 20, 2014·Journal of Pharmaceutical and Biomedical Analysis·Jin Joo HaMyung Ho Hyun

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