Enantioselective fractionation of fluoroquinolones in the aqueous environment using chiral liquid chromatography coupled with tandem mass spectrometry

Chemosphere
Erika CastrignanòBarbara Kasprzyk-Hordern

Abstract

This paper aims to examine the multiresidue enantiomeric profiling of (fluoro)quinolones and their metabolites in solid and liquid environmental matrices using chiral HPLC-MS/MS method and a CHIRALCEL® OZ-RH column. Simultaneous chiral separation was obtained for chiral ofloxacin and its main metabolites ofloxacin-N-oxide and desmethyl-ofloxacin; moxifloxacin; the prodrug prulifloxacin and its active compound ulifloxacin; flumequine; nadifloxacin and R-(+)-besifloxacin. Achiral antibiotics (ciprofloxacin, norfloxacin and nalidixic acid) were also included in the method to enable the analysis of all targeted quinolones within one analytical run. Satisfactory enantiomeric resolution (Rs ≥ 1) was obtained for five out of eight chiral drugs enabling quantitative analysis. The overall performance of the method was satisfactory with a method precision <20%, relative recoveries >70% for most of the analytes and method detection limits (MDL) at low ng L-1 levels (0.1 < MDL (ng L-1)< 6.4, 0.1 < MDL (ng L-1)< 6.6 and 0.1 < MDL (ng L-1)< 7.0 in influent, effluent and river waters for 83% compounds, 0.01 < MDL (ng g-1)< 4.9 in solids for 91% compounds). Enantiomeric profiling from a week-long monitoring campaign in the UK showed that (±)-o...Continue Reading

Citations

Aug 20, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Daniel D SnowJonathan Brett Sallach
Nov 22, 2019·European Journal of Pharmacology·Ewa FelisEwa Korzeniewska
May 4, 2021·Frontiers in Microbiology·Felicity C T ElderBarbara Kasprzyk-Hordern
May 7, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Meiyu ZhangLimin He
Aug 12, 2021·Environmental Toxicology and Chemistry·Jamie HarrowerKarin Helwig

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