Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex

Organic & Biomolecular Chemistry
Jimil George, B V Subba Reddy

Abstract

The glucosamine derived glucoBOX-Cu(II) complex was found to be a unique catalytic system for enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-1-oxides. A large number of 3-alkylated indole derivatives were prepared using 5 mol% glucoBOX-Cu(II) complex in excellent yields with high enantioselectivity up to 99% ee.

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Citations

Apr 13, 2017·Organic & Biomolecular Chemistry·Jing-Biao Chen, Yi-Xia Jia
Nov 22, 2014·Organic & Biomolecular Chemistry·Alexander GrataisSamir Bouzbouz
Feb 2, 2017·Beilstein Journal of Organic Chemistry·Serena TraboniAlfonso Iadonisi
Aug 20, 2020·Chemical Communications : Chem Comm·Xinping LiangZhiyong Wang
Sep 11, 2012·The Journal of Organic Chemistry·Sumit K RayVinod K Singh

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