Enantioselective separation of RS-mandelic acid using β-cyclodextrin modified Fe3 O4 @SiO2 /Au microspheres

The Analyst
Xiaojuan DengXiaoping Chen

Abstract

Chiral magnetic microspheres show great potential in direct enantioseparation. Herein novel chiral magnetic microspheres were prepared by self-assembling β-cyclodextrin on magnetic Fe3O4@SiO2/Au composite microspheres. The prepared materials were characterized by transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR). The results showed that the functional microspheres have a three-ply structure and high saturation magnetization. β-Cyclodextrin-immobilized magnetic Fe3O4@SiO2/Au microspheres (Fe3O4@SiO2/Au/β-CD) were applied in the direct chiral separation of RS-mandelic acid. The analysis results of HPLC revealed that the Fe3O4@SiO2/Au/β-CD magnetic microspheres exhibited stronger enantioselective adsorption for R-mandelic acid than S-mandelic acid. The chiral selector functionalized magnetic microspheres are therefore expected to be an efficient and economical chiral separation method for use in further research.

References

Feb 24, 2001·Journal of Chromatography. a·N M MaierW Lindner
Mar 31, 2005·Angewandte Chemie·Hong DengYadong Li
Feb 6, 2007·Angewandte Chemie·An-Hui LuFerdi Schüth
May 30, 2009·Accounts of Chemical Research·Jinhao GaoBing Xu
Aug 5, 2009·Electrophoresis·Peter Mikus, Katarína Maráková
Mar 31, 2011·Advanced Drug Delivery Reviews·Challa S S R Kumar, Faruq Mohammad
Apr 14, 2011·Chirality·Chao MaLi-Ming Yuan
Mar 1, 2012·Journal of Pharmaceutical and Biomedical Analysis·Katrijn De KlerckYvan Vander Heyden
Feb 7, 2013·Colloids and Surfaces. B, Biointerfaces·Sudipa GhoshK Hidajat
Jun 21, 2014·Journal of Chromatography. a·L Escuder-GilabertS Sagrado
Sep 24, 2014·Chemical Reviews·Grégorio Crini
Jun 30, 2016·Chemical Reviews·Liheng WuShouheng Sun
Oct 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Avvaru Praveen KumarYong-Ill Lee
Oct 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yingying WangYi Yang
Feb 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingwei WuYi Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
NMR
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.