PMID: 32510073DOI: 10.1039/d0cc03158eJun 9, 2020Paper
Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation.
Chemical Communications : Chem Comm
Sifeng LiJun Joelle Wang
Abstract
An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.
References
Jul 19, 2001·Journal of the American Chemical Society·M Lautens, K Fagnou
Dec 4, 2003·Journal of the American Chemical Society·Mark LautensDingqiao Yang
Feb 14, 2004·The Journal of Organic Chemistry·Kou HiroyaTakao Sakamoto
Jul 14, 2005·Chemical Reviews·Sandro Cacchi, Giancarlo Fabrizi
Nov 18, 2005·Organic Letters·Xingwei LiRobert H Crabtree
Feb 14, 2006·Organic Letters·Matthew TudgeGuy R Humphrey
Mar 12, 2009·Journal of the American Chemical Society·Barry M TrostJ Du Bois
Aug 20, 2009·Chemical Society Reviews·Zhihui Shao, Hongbin Zhang
Jan 7, 2010·Chemistry, an Asian Journal·Jian Zhou
Jan 19, 2010·Chemistry : a European Journal·Mónica TrincadoClaudio Bianchini
Feb 4, 2010·Beilstein Journal of Organic Chemistry·Dingqiao YangXiongjun Zuo
Nov 4, 2010·Organic Letters·Robert WebsterMark Lautens
May 18, 2011·Organic & Biomolecular Chemistry·Huifeng WangChunying Duan
Jun 24, 2011·Angewandte Chemie·Alistair Boyer, Mark Lautens
Aug 2, 2011·Accounts of Chemical Research·Jie YuLiu-Zhu Gong
Sep 16, 2011·Angewandte Chemie·Jane PanteleevMark Lautens
Mar 27, 2012·Chemical Society Reviews·Mélanie PlatonJean-Cyrille Hierso
Oct 9, 2012·Angewandte Chemie·Feng Shi, Liu-Zhu Gong
Oct 16, 2012·Organic Letters·Gavin Chit TsuiMark Lautens
Jul 23, 2013·Angewandte Chemie·Adam A FriedmanMark Lautens
Sep 17, 2013·Chemical Communications : Chem Comm·Renshi LuoAlbert S C Chan
Mar 29, 2014·Chemistry : a European Journal·Ke-Yin YeShu-Li You
Apr 1, 2014·Chemistry : a European Journal·Oleg S MorozovMikhail S Nechaev
Jun 10, 2014·Accounts of Chemical Research·Dian-Feng ChenLiu-Zhu Gong
Aug 15, 2014·The Journal of Organic Chemistry·Ze-Peng YangShu-Li You
Sep 27, 2014·Angewandte Chemie·Lei ZhangMark Lautens
Oct 23, 2014·The Journal of Organic Chemistry·Lei ZhangMark Lautens
Feb 11, 2015·Organic Letters·Zhishi YeMingji Dai
Mar 13, 2015·Organic Letters·Saori NaoeHiroaki Ohno
Apr 25, 2015·Chemistry : a European Journal·Sifeng LiJun Wang
Jul 17, 2015·Organic & Biomolecular Chemistry·Chaoyuan ZengBaomin Fan
Aug 28, 2015·Journal of the American Chemical Society·Paula Rubio-MarquésAvelino Corma
Sep 4, 2015·Journal of Medicinal Chemistry·Nikolaos EleftheriadisFrank J Dekker
Oct 9, 2015·Journal of Medicinal Chemistry·Sagit AzranBilha Fischer
Dec 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen YangDingqiao Yang
Dec 10, 2015·Chemical Communications : Chem Comm·A ArcadiV Michelet
Jan 28, 2016·Organic & Biomolecular Chemistry·Xin XuBaomin Fan
Mar 5, 2016·Journal of Medicinal Chemistry·Gaozhi ChenGuang Liang
Apr 1, 2016·Journal of Medicinal Chemistry·Fei ZhaoHong Liu
Apr 27, 2016·European Journal of Medicinal Chemistry·Margiani P FortesClaudio C Silveira
May 5, 2016·Journal of Medicinal Chemistry·Zhiguo LiuGuang Liang
Oct 22, 2016·Organic Letters·Sifeng LiJun Wang
Feb 22, 2017·Organic Letters·Yi-Jin LiYu-Long Zhao
Apr 17, 2017·European Journal of Medicinal Chemistry·Navriti Chadha, Om Silakari
May 10, 2017·Organic Letters·Zong-Feng ZhangMing-Hua Xu
May 26, 2017·Journal of the American Chemical Society·Takuma WatanabeShinichi Saito
May 30, 2017·Chemical Science·Lan ZhangBo Liu
Jun 2, 2017·Chemical Communications : Chem Comm·Soumitra AgastiDebabrata Maiti
Oct 11, 2017·Organic Letters·Hyunseok KimPhil Ho Lee
Nov 21, 2017·Bioorganic & Medicinal Chemistry Letters·Allan M PriorDianqing Sun
❮ Previous
Next ❯
Citations
Sep 5, 2020·Pharmaceuticals·Volodymyr HorishnyPhaedra Eleftheriou
Feb 6, 2021·Chemical Society Reviews·Sundaravel Vivek KumarPatrick J Guiry
Feb 23, 2021·The Journal of Organic Chemistry·Yuting QiuJingping Zhang
Sep 29, 2021·Angewandte Chemie·Zhiping Yang, Jun Joelle Wang
❮ Previous
Next ❯
Methods Mentioned
BETA
hydroamination
X-ray
ELISA
Software Mentioned
CDOCKER
Discovery Studio
Related Concepts
Related Feeds
Anti-inflammatory Treatments
A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here
Related Papers
American Journal of Medical Genetics
A G HunterF G Tawagi
Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Mark A NewtonJohn Evans
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
R S LarsonJ Kissane
European Journal of Medicinal Chemistry
Yong-Tao DuanHai-Liang Zhu