Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation.

Chemical Communications : Chem Comm
Sifeng LiJun Joelle Wang

Abstract

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

References

Jul 14, 2005·Chemical Reviews·Sandro Cacchi, Giancarlo Fabrizi
Feb 14, 2006·Organic Letters·Matthew TudgeGuy R Humphrey
Mar 12, 2009·Journal of the American Chemical Society·Barry M TrostJ Du Bois
Aug 20, 2009·Chemical Society Reviews·Zhihui Shao, Hongbin Zhang
Jan 7, 2010·Chemistry, an Asian Journal·Jian Zhou
Feb 4, 2010·Beilstein Journal of Organic Chemistry·Dingqiao YangXiongjun Zuo
Jun 24, 2011·Angewandte Chemie·Alistair Boyer, Mark Lautens
Oct 16, 2012·Organic Letters·Gavin Chit TsuiMark Lautens
Sep 17, 2013·Chemical Communications : Chem Comm·Renshi LuoAlbert S C Chan
Jun 10, 2014·Accounts of Chemical Research·Dian-Feng ChenLiu-Zhu Gong
Aug 15, 2014·The Journal of Organic Chemistry·Ze-Peng YangShu-Li You
Oct 23, 2014·The Journal of Organic Chemistry·Lei ZhangMark Lautens
Jul 17, 2015·Organic & Biomolecular Chemistry·Chaoyuan ZengBaomin Fan
Aug 28, 2015·Journal of the American Chemical Society·Paula Rubio-MarquésAvelino Corma
Sep 4, 2015·Journal of Medicinal Chemistry·Nikolaos EleftheriadisFrank J Dekker
Dec 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen YangDingqiao Yang
Apr 27, 2016·European Journal of Medicinal Chemistry·Margiani P FortesClaudio C Silveira
Apr 17, 2017·European Journal of Medicinal Chemistry·Navriti Chadha, Om Silakari
May 26, 2017·Journal of the American Chemical Society·Takuma WatanabeShinichi Saito
Jun 2, 2017·Chemical Communications : Chem Comm·Soumitra AgastiDebabrata Maiti

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Methods Mentioned

BETA
hydroamination
X-ray
ELISA

Software Mentioned

CDOCKER
Discovery Studio

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