Enantioselective Synthesis of Tetrahydroquinolines by Borrowing Hydrogen Methodology: Cooperative Catalysis by an Achiral Iridacycle and a Chiral Phosphoric Acid

Angewandte Chemie
Ching-Si LimYu Zhao

Abstract

We report herein the highly enantioselective synthesis of 2-substituted tetrahydroquinolines through borrowing hydrogen, a process recognized for its environmentally benign and atom-economical nature. The use of an achiral iridacycle complex in combination with a chiral phosphoric acid as catalysts was the key to the development of this highly efficient and enantioselective transformation.

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Citations

Feb 28, 2020·Chemical Communications : Chem Comm·Daniella M J CheangTimothy J Donohoe
Feb 28, 2020·Chemical Communications : Chem Comm·Anna E R ChamberlainTimothy J Donohoe
Apr 16, 2020·Angewandte Chemie·Kun WangChao Wang
Apr 17, 2020·Chemistry : a European Journal·Timothy KwokTimothy James Donohoe
May 4, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Zhenyu ChenJianliang Xiao
Jun 1, 2021·ACS Central Science·Benjamin G Reed-BerendtLouis C Morrill
Apr 10, 2019·Chemical Reviews·Isravel MuthukrishnanJ Carlos Menéndez
Aug 21, 2021·Nature Communications·Yongbing LiuYu Zhao
Jan 6, 2018·Journal of the American Chemical Society·Matthew R PorterJoseph J Topczewski
Oct 26, 2018·Journal of the American Chemical Society·Rui-Zhi HuangYu Zhao
Jun 12, 2018·The Journal of Organic Chemistry·Maïwenn JacolotFlorence Popowycz
May 29, 2018·Organic Letters·Linwei ZengSunliang Cui
Dec 4, 2021·Journal of the American Chemical Society·Xianghong XuChang Guo

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