Enantioselective synthesis utilizing enantiomorphous organic crystal of achiral benzils as a source of chirality in asymmetric autocatalysis

Organic Letters
Tsuneomi KawasakiKenso Soai

Abstract

Chiral crystals of achiral benzils act as efficient chiral initiators of asymmetric autocatalysis to afford highly enantioenriched pyrimidyl alkanols whose absolute configurations depend upon the enantiomorph of the crystal used in conjunction with asymmetric autocatalysis with amplification of enantiomeric excess.

References

Jun 26, 1999·Science·A Eschenmoser
Dec 22, 1999·Angewandte Chemie·B L Feringa, van Delden RA
Jul 13, 2000·Accounts of Chemical Research·K SoaiI Sato
Mar 7, 2001·Cellular and Molecular Life Sciences : CMLS·J Podlech
Jun 1, 1995·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·W A Bonner
Oct 11, 2001·Journal of the American Chemical Society·D G BlackmondJ M Brown
Dec 19, 2001·Accounts of Chemical Research·D K Kondepudi, K Asakura
Dec 26, 2001·Chemical Reviews·K Tanaka, F Toda
Mar 15, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·K SoaiT Shibata
Jan 4, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tsonko M Kolev, Bistra A Stamboliyska
Aug 14, 2003·Chemical Reviews·Koichi Mikami, Masahiro Yamanaka
Apr 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Donna G Blackmond
Aug 4, 2005·Angewandte Chemie·Joachim Podlech, Timo Gehring
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jesús Rivera IslasThomas Buhse
May 4, 2006·Journal of the American Chemical Society·Tsuneomi KawasakiKenso Soai
May 5, 2006·The Journal of Physical Chemistry. a·Karoly MicskeiGyula Palyi
Jul 27, 2007·Chemical Communications : Chem Comm·Jürgen KlankermayerJohn M Brown
Jul 8, 2008·Angewandte Chemie·Kacey ClabornBart Kahr
Mar 1, 1999·Angewandte Chemie·Takanori ShibataKenso Soai

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Citations

Nov 26, 2009·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Michiya Fujiki
Nov 17, 2009·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Tsuneomi KawasakiKenso Soai
Mar 12, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Kenso Soai
Dec 15, 2017·Journal of the Royal Society, Interface·Josep M RibóAlbert Moyano
Jan 23, 2014·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kenso SoaiArimasa Matsumoto

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