Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (-)-2(S)-Cathafoline, and (-)-Aspidophylline A

Journal of the American Chemical Society
Jesus MorenoNeil K Garg

Abstract

The akuammiline alkaloids are a family of natural products that have been widely studied for decades. Although notable synthetic achievements have been made recently, akuammilines that possess a methanoquinolizidine core have evaded synthetic efforts. We report an asymmetric approach to these alkaloids, which has culminated in the first total syntheses of (-)-2(S)-cathafoline and the long-standing target (+)-strictamine. Moreover, the first enantioselective total synthesis of aspidophylline A is described.

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Citations

Mar 11, 2016·Journal of the American Chemical Society·Yong LiAng Li
Mar 25, 2016·Organic Letters·Daisuke NishiyamaHiroaki Ohno
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