Enantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups

Angewandte Chemie
Hao ChenMengchun Ye

Abstract

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved, providing a series of chiral ferrocenes in 40-98% yield and 93-99% ee. Bulky chiral SPO ligand-enabled Ni-Al bimetallic catalysis proved to be critical to high reactivity and high selectivity.

References

Jul 13, 2000·Accounts of Chemical Research·G C Fu
Oct 18, 1996·The Journal of Organic Chemistry·J. Craig Ruble, Gregory C. Fu
Aug 18, 2004·Accounts of Chemical Research·Gregory C Fu
Oct 22, 2004·Angewandte Chemie·Natalia V Dubrovina, Armin Börner
Nov 23, 2006·Accounts of Chemical Research·Gregory C Fu
Jan 11, 2007·Chemical Reviews·Dino AlbericoMark Lautens
Jun 7, 2007·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tetsuhiro Nemoto, Yasumasa Hamada
Jun 14, 2008·Chemistry : a European Journal·Yao-Ting WuTsun-Cheng Wu
Jan 20, 2009·Reviews on Recent Clinical Trials·Anna CapassoWalter Milano
Apr 9, 2009·Journal of the American Chemical Society·Yoshiaki NakaoTamejiro Hiyama
Jan 30, 2010·Chemical Society Reviews·James A Ashenhurst
May 8, 2010·Chemical Communications : Chem Comm·Tatsuya FukutaniMasahiro Miura
Aug 27, 2010·Chemistry : a European Journal·Tetsuya Satoh, Masahiro Miura
Feb 24, 2011·Journal of the American Chemical Society·Yoshiaki NakaoTamejiro Hiyama
Aug 9, 2011·The Journal of Organic Chemistry·Guoyong SongXingwei Li
Mar 2, 2012·Chemical Society Reviews·Guoyong SongXingwei Li
Jun 21, 2012·Chemistry : a European Journal·Ji-Rong HuangYing-Chun Chen
Sep 22, 2012·Angewandte Chemie·Nadine KuhlFrank Glorius
Aug 6, 2013·Journal of the American Chemical Society·Pavel A Donets, Nicolai Cramer
Sep 26, 2013·Beilstein Journal of Organic Chemistry·Yan-Chao ShiShu-Li You
Jun 17, 2014·Chemical Communications : Chem Comm·Jun Zheng, Shu-Li You
Nov 8, 2014·Angewandte Chemie·Pavel A Donets, Nicolai Cramer
Feb 18, 2015·Chemical Communications : Chem Comm·Takanori ShibataTomoya Sasaki
May 15, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Luis A López, Enol López
Jan 14, 2016·Chemical Communications : Chem Comm·Yudong YangJingsong You
Feb 20, 2016·The Journal of Organic Chemistry·Keita FukuzumiMasahiro Miura
Jun 23, 2016·Angewandte Chemie·Moisés Gulías, José Luis Mascareñas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.