Enantioseparation of tiropramide by HPLC

Chirality
Jae Jeong RyooWonjae Lee

Abstract

Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

References

Feb 15, 1988·Biomedical & Environmental Mass Spectrometry·R ArigoniR Fanelli
Sep 19, 2002·Journal of Chromatography. a·Catherine A RimmerJohn G Dorsey
Feb 1, 2003·Journal of Pharmaceutical and Biomedical Analysis·Soo Kyoung BaekHye Suk Lee
Jun 6, 2003·Archives of Pharmacal Research·Oh-Seung KwonYoun Bok Chung
Oct 29, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hye Won LeeHye Suk Lee

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