PMID: 15223826Jun 30, 2004Paper

Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology

Investigative Ophthalmology & Visual Science
Ronald A BushPaul A Sieving

Abstract

ERG and histologic changes were investigated in normal rabbits after intravitreal implantation of encapsulated cell technology (ECT) devices releasing ciliary neurotrophic factor (CNTF). Fifteen adult New Zealand White albino rabbits had ECT devices secreting CNTF at 22, 5, or 0 ng/d implanted in the superior temporal quadrant of the left eye. The low dose has been shown to produce substantial rescue of photoreceptors in the rcd1 canine model of retinal degeneration. Right eyes were untreated. Ganzfeld dark- and light-adapted ERGs and clinical observations were performed at 5, 15, and 25 days after implantation. Rod a-waves and rod and cone b-waves and outer nuclear layer (ONL) morphology were evaluated at 25 days. Clinical examination showed minimal changes in a few CNTF-treated eyes, including vitreous membranes and engorgement of iris vessels at day 25. Retinas appeared normal. CNTF did not significantly affect the rod a- or b-waves, although the b-wave amplitude tended to be larger in CNTF-treated retinas at low flash intensities. The cone b-wave amplitude was significantly reduced in high-dose eyes at some flash intensities. The ONL area in high-dose eyes was significantly greater because of increased thickness than in fel...Continue Reading

Citations

Dec 21, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·An TruongLevon M Khachigian
Oct 27, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Joseph M HarrisonRobert Melendez
Sep 2, 2008·Pharmaceutical Research·Ripal GaudanaAshim K Mitra
Nov 18, 2011·Gene Therapy·G J FarrarP F Kenna
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kang ZhangGeorge A Williams
Apr 13, 2011·Human Gene Therapy·J Timothy Stout, Peter J Francis
Aug 13, 2011·Retina·Rong ZhangJost B Jonas
Mar 3, 2007·The Journal of Clinical Investigation·Martin Friedlander
Jan 29, 2010·Drugs & Aging·Noriyuki Kuno, Shinobu Fujii
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Paul A SievingRonald A Bush
Aug 13, 2015·Journal of Functional Biomaterials·Darren J Lee
May 15, 2013·American Journal of Ophthalmology·David G BirchUNKNOWN Ciliary Neurotrophic Factor Retinitis Pigmentosa Study Groups
Dec 21, 2011·Progress in Retinal and Eye Research·Rong WenPaul A Sieving
Apr 20, 2010·Progress in Retinal and Eye Research·M El SanharawiF Behar-Cohen
Aug 27, 2010·Acta Ophthalmologica·Rutledge Ellis-Behnke, Jost B Jonas
Nov 17, 2006·Advanced Drug Delivery Reviews·J L BourgesF Behar-Cohen
Sep 12, 2006·Progress in Retinal and Eye Research·Alan R HarveyQi Cui
Nov 18, 2005·Experimental Eye Research·Hyuncheol KimMichael R Robinson
Sep 7, 2005·Experimental Eye Research·Caroline J ZeissWeng Tao
Sep 17, 2004·The Journal of Clinical Investigation·Lois E H Smith
Dec 23, 2014·American Journal of Ophthalmology·Emily Y ChewUNKNOWN MacTel-CNTF Research Group
Jun 25, 2016·BioImpacts : BI·Jaleh BararYadollah Omidi
Jul 29, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Prateek K BuchRobin R Ali
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kun Do RheeXian-Jie Yang
Mar 18, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Jan LuebkeMichael Bach
Jan 13, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Najam A Sharif
Oct 18, 2020·Antioxidants·Paolo Giuseppe LimoliMarcella Nebbioso
Feb 13, 2008·Journal français d'ophtalmologie·J-L BourgesF Behar-Cohen

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