Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrence

British Medical Bulletin
D W Gray

Abstract

Immuno-isolation of islet tissue for the purpose of curing diabetes without immunosuppression is an attractive concept that has been extensively investigated over the last 20 years. Rather than give a detailed review of the past and present history of the immuno-isolation or encapsulation approach for islet transplantation, this paper will examine the concepts behind encapsulation, concentrating on the immune mechanisms involved.

Citations

Aug 16, 2000·Advanced Drug Delivery Reviews·H UludagP A Tresco
May 18, 1999·Molecular Medicine Today·F Levine, G Leibowitz
May 26, 2007·Tissue Engineering·Jennifer J Vallbacka, Michael V Sefton
Dec 16, 2004·Transplantation·Kim S JonesReginald M Gorczynski
Aug 7, 2013·Advanced Drug Delivery Reviews·David W Scharp, Piero Marchetti
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alice A TomeiJeffrey A Hubbell
Aug 13, 2002·Expert Opinion on Biological Therapy·Tejal A Desai
Jan 9, 2003·Expert Opinion on Biological Therapy·Dwaine F Emerich
Nov 21, 2007·Advanced Drug Delivery Reviews·John T Wilson, Elliot L Chaikof
Apr 29, 2014·Journal of Biomedical Materials Research. Part a·Ronke M Olabisi
Sep 8, 2004·Advanced Drug Delivery Reviews·Tejal A DesaiArfaan Rampersaud
Mar 21, 2006·Protein Expression and Purification·Michael D Kulis, Suzanne B Shuker
Jun 1, 2005·Journal of Biotechnology·Jian-Hang ZhuHanry Yu
Sep 26, 2009·Current Opinion in Organ Transplantation·Olle Korsgren, Bo Nilsson
Aug 9, 2002·Upsala Journal of Medical Sciences·A King

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