Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study.

Human Pathology
Michael RiveraRonald Ghossein

Abstract

Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming from their rarity, low-stage, high-grade appearance, and lack of long-term follow-up studies. All cases of EFHG were defined as encapsulated tumors of follicular cell origin with at least 5 mitoses per 10 high-power fields and/or tumor necrosis. Available tissues were subjected to a thyroid carcinoma platform for mass spectrometry high-throughput genotyping, which consisted of 111 known mutations in 16 different genes: BRAF, RET, NRAS, HRAS, KRAS, PIK3CA, AKT1, and other related genes. Twenty-five cases met the selection criteria. Tumor necrosis was present in 56.0% (n = 14). Extensive vascular invasion was identified in 24.0% (n = 6). Eight (32%) of 25 tumors were noninvasive. Twenty-two patients (88%) were free of disease (median follow up: 8.5 years). All 8 noninvasive tumor did not recur despite focal/extensive tumor necrosis in 3 cases and a median follow-up of 11.9 years. EFHG with no vascular invasion did not...Continue Reading

References

Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·W LangE Kienzle
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·V VaskoC de Micco
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ginesa Garcia-RostanGiovanni Tallini
Nov 30, 2006·Journal of Surgical Oncology·Ronald A DeLellis
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peng HouMingzhao Xing

❮ Previous
Next ❯

Citations

Jan 12, 2011·Head and Neck Pathology·Ricardo V LloydElham Khanafshar
May 29, 2014·Thyroid : Official Journal of the American Thyroid Association·Gregory DibeliusBruce M Wenig
May 31, 2011·The Annals of Thoracic Surgery·Juan Rosai
Jun 26, 2013·CA: a Cancer Journal for Clinicians·David F Schneider, Herbert Chen
Mar 7, 2015·Seminars in Diagnostic Pathology·Lauren L Ritterhouse, Justine A Barletta
Dec 1, 2014·Surgical Pathology Clinics·Namrata Setia, Justine A Barletta
Feb 7, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Ewa ChmielikBarbara Jarzab
Feb 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Rossella Elisei
Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bayan AlzumailiRonald A Ghossein
Oct 5, 2011·Endocrine Pathology·Giovanni Tallini
Oct 12, 2012·Pathology Oncology Research : POR·Hayam A AiadAhmad A Zahran
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cristina Montero-CondeJames A Fagin
Dec 12, 2018·Pathology International·Kennichi KakudoChan Kwon Jung
Mar 27, 2019·Endocrinology and Metabolism·Young Shin Song, Young Joo Park
Jul 16, 2017·Endocrine Pathology·Vincent CracoliciNicole A Cipriani
Jan 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rebecca D ChernockYuri E Nikiforov
Apr 26, 2021·Journal of Comparative Pathology·Fernando F ArgentaLuciana Sonne
Nov 4, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bin XuRonald A Ghossein

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.