Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes

ACS Omega
Sieun ChaeByumseok Koh

Abstract

The topoisomerase I inhibitors SN-38 and camptothecin (CPT) have shown potent anticancer activity, but water insolubility and metabolic instability limits their clinical application. Utilizing carbon nanotubes as a protective shell for water-insoluble SN-38 and CPT while maintaining compatibility with aqueous media via a carboxylic acid-functionalized surface can thus be a strategy to overcome this limitation. Through hydrophobic-hydrophobic interactions, SN-38 and CPT were successfully encapsulated in carboxylic acid functionalized single-walled carbon nanotubes and dispersed in water. The resulting cell proliferation inhibition and drug distribution profile inside the cells suggest that these drug-encapsulated carbon nanotubes can serve as a promising delivery strategy for water-insoluble anticancer drugs.

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Citations

Feb 28, 2020·International Journal of Molecular Sciences·Soul-Hee LeeByumseok Koh
Jul 18, 2020·Organic & Biomolecular Chemistry·Andrzej S SkwareckiMaria J Milewska
Oct 12, 2019·F1000Research·Mary-Ann Bjornsti, Scott H Kaufmann
Jan 16, 2020·Topics in Current Chemistry·Viviana NegriPilar López-Larrubia

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Methods Mentioned

BETA
transmission electron microscopy

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