Encapsulation and stabilization of gold nanoparticles with "click" polyethyleneglycol dendrimers

Journal of the American Chemical Society
Elodie BoisselierDidier Astruc

Abstract

Water-soluble arene-cored "clicked" and non-"clicked" dendrimers terminated by 27, 81, and 243 triethyleneglycol (TEG) tethers (respectively generations G0, G1, and G2) have been synthesized and shown to form dendrimer-encapsulated gold nanoparticles (DEAuNPs) and dendrimer-stabilized gold nanoparticles (DSAuNPs). The dendrimers have been characterized by IR, (1)H NMR, (13)C NMR, size-exclusion chromatography, elemental analysis, MALDI-TOF mass spectroscopy, DOSY NMR, and dynamic light scattering. The AuNPs have been generated and stabilized by these PEGylated dendrimers using a variety of reduction modes, including NaBH(4) in methanol, various single-electron metallocene-type reductants, and even in the absence of additional reductants. The active role of the "clicked" triazole rings, dendrimer generation, stoichiometry of Au precursor, and nature of the reductant and of the solvent are delineated, leading to DSAuNPs with the G0 dendrimer and smaller DEAuNPs with the G1 and G2 dendrimers. Altogether, AuNPs in the size range from 1.8 to 42 nm were formed and characterized by transmission electron microscopy (TEM), high resolution TEM (HRTEM) and UV-vis spectroscopy. Both 1,2,3-triazole and PEGylated Percec-type dendrons are req...Continue Reading

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M LiuJ M Fréchet
Sep 29, 2000·Organic Letters·M HiguchiK Yamamoto
Jul 18, 2001·Journal of the American Chemical Society·M HiguchiK Yamamoto
Dec 13, 2001·Chemical Reviews·S M Grayson, J M Fréchet
Feb 2, 2002·Nature·Kimihisa YamamotoHiroshi Chiba
Mar 28, 1996·Chemical Reviews·Neil G. Connelly, William E. Geiger
Dec 31, 2002·Journal of Colloid and Interface Science·Tomokazu YoshimuraKunio Esumi
Mar 27, 2003·Journal of the American Chemical Society·Robert W J ScottRichard M Crooks
May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
Jun 12, 2003·Journal of the American Chemical Society·Jaime RuizDidier Astruc
Jul 3, 2003·Journal of the American Chemical Society·Norifusa SatohKimihisa Yamamoto
Jan 23, 2004·Chemical Society Reviews·Ulrik Boas, Peter M H Heegaard
Feb 12, 2004·Journal of the American Chemical Society·Masahiko OoeKiyotomi Kaneda
Jun 19, 2004·Drug Delivery·Giulio F PaciottiLawrence Tamarkin
Aug 28, 2004·Organic Letters·Timothy R ChanValery V Fokin
Sep 17, 2004·Chemistry : a European Journal·Ulf DrechslerVincent M Rotello
Nov 13, 2004·Angewandte Chemie·Eugenii Katz, Itamar Willner
Nov 26, 2004·Journal of the American Chemical Society·Robert W J ScottRichard M Crooks
Nov 30, 2004·Chemical Communications : Chem Comm·Didier AstrucJaime Ruiz
Feb 3, 2005·Journal of the American Chemical Society·Robert W J ScottRichard M Crooks
Jun 29, 2005·Chemical Communications : Chem Comm·Albertus P H J Schenning, E W Meijer
Nov 22, 2005·Advanced Drug Delivery Reviews·Ruth Duncan, Lorella Izzo
Nov 25, 2005·Advanced Drug Delivery Reviews·Sönke Svenson, Donald A Tomalia
Nov 29, 2005·Advanced Drug Delivery Reviews·Antony D'Emanuele, David Attwood
Jul 27, 2006·The Journal of Physical Chemistry. B·Robert W J ScottRichard M Crooks
Feb 17, 2007·Chemistry : a European Journal·Virgil PercecPaul A Heiney
Nov 18, 1994·Science·J F JansenE W Meijer
Jan 23, 2008·Chemical Communications : Chem Comm·Catherine J MurphyPatrick Hankins
Mar 26, 2008·Chemical Communications : Chem Comm·Cátia OrnelasDidier Astruc
Apr 29, 2008·Inorganic Chemistry·Sihem BadècheDidier Astruc
May 16, 2008·Chemical Communications : Chem Comm·Nicolas CandelonJean-Marc Vincent
Sep 6, 2008·Journal of the American Chemical Society·Virgil PercecPaul A Heiney
Oct 3, 2008·Chemical Communications : Chem Comm·Elodie BoisselierDidier Astruc
Oct 16, 2008·Current Topics in Medicinal Chemistry·Istvan J MajorosJames R Baker

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Citations

Nov 13, 2013·Accounts of Chemical Research·Christophe Deraedt, Didier Astruc
Jul 2, 2011·Chemical Reviews·Lyudmila M Bronstein, Zinaida B Shifrina
Apr 11, 2012·Chemical Reviews·Jingjing HuYiyun Cheng
May 23, 2013·Inorganic Chemistry·Amalia RapakousiouDidier Astruc
May 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mathieu ArseneaultJean-François Morin
Oct 7, 2011·The Journal of Chemical Physics·Denis A MarkelovNatalia I Boiko
Sep 15, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Suprit DeolYoung-Seok Shon
Apr 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Didier AstrucQi Wang
May 17, 2018·Medicinal Research Reviews·Florence MasseElodie Boisselier
Sep 25, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hiroya SakuraiTatsuo Arai
Oct 17, 2014·Chemistry, an Asian Journal·Tianyi QinYi Li
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Didier AstrucJaime Ruiz
Jul 26, 2011·Chemical Society Reviews·Audrey Llevot, Didier Astruc
Jan 17, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·A TuchschererH Lang
Jun 4, 2014·Chemistry : a European Journal·Na LiDidier Astruc
Apr 22, 2020·Biomaterials Science·Mohamed F AttiaFrank Alexis
Jan 11, 2018·Chemistry, an Asian Journal·Li QiuWei Zhang
Apr 17, 2010·Chemistry : a European Journal·Elodie BoisselierDidier Astruc
Aug 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florence MasseElodie Boisselier
Aug 18, 2020·Beilstein Journal of Nanotechnology·Sébastien GottisAnne-Marie Caminade
Jan 29, 2011·Angewandte Chemie·Ajay S KarakotiSudipta Seal
Oct 27, 2011·Chemistry : a European Journal·Jens Peter HermesMarcel Mayor
Dec 6, 2019·Frontiers in Bioengineering and Biotechnology·Yu YangXinxin Li
Jun 26, 2020·Chemical Reviews·Chuanbo GaoYadong Yin
Oct 28, 2010·Journal of the American Chemical Society·Ilhem F HakemMichael R Bockstaller
Jul 30, 2010·Chemical Reviews·George R Newkome, Carol Shreiner
Oct 10, 2020·Accounts of Chemical Research·Changlong WangDidier Astruc
Jan 18, 2014·Journal of the American Chemical Society·Ryan McCaffreyWei Zhang

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