Encapsulation is a significant prognostic factor for better outcome in large hepatocellular carcinoma

Journal of Surgical Oncology
Tsung-Han WuMiin-Fu Chen


The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type) and 349 patients without tumor encapsulation (NC type). Clinicopathological factors, surgical outcome, and long-term survival were analyzed. Disease-free survival (DFS) was affected by surgical margin involvement, the presence of surgical complications, vascular invasion, liver cirrhosis, tumor encapsulation, tumor size >5 cm, tumor rupture, and the presence of satellite lesions (all, P < 0.05). Overall survival (OS) was also affected by the same parameters, except for satellite lesions. When the patients were grouped by tumor size >5 or ≤5 cm, the protective effect of encapsulation was only observed when the tumor size was >5 cm [odds ratio (OR) for DFS = 0.75, P = 0.02; OR for OS = 0.68, P < 0.01]. Tumor encapsulation is a significant prognostic factor for HCC >5 cm.


May 31, 2014·World Journal of Gastroenterology : WJG·Antonio ColecchiaDavide Festi
Aug 5, 2014·Magnetic Resonance Imaging Clinics of North America·Daniel C Barr, Hero K Hussain
Mar 13, 2014·World Journal of Gastroenterology : WJG·Zhe GuoBang-De Xiang
Jan 4, 2012·Journal of Surgical Oncology·Shun-Ichi Ariizumi, Masakazu Yamamoto
Jun 17, 2016·Molecular & Cellular Oncology·Violaine Moreau, Frédéric Saltel
Sep 19, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hong-Chuan ZhaoXiao-Ping Geng
Sep 29, 2020·Frontiers in Oncology·Margaux SalaFrédéric Saltel
Sep 2, 2018·Abdominal Radiology·Chansik An, Myeong-Jin Kim
Aug 18, 2018·Journal of Gastrointestinal Cancer·Richard H LewisPaxton V Dickson
Oct 18, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wei ZhangXiao-Ping Chen
May 10, 2018·Journal of Gastrointestinal Cancer·Narendra PanditShailesh Adhikary


Apr 15, 1990·International Journal of Cancer. Journal International Du Cancer·W F GrigioniS Garbisa
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E C LaiJ Wong
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H EnzanH Hara
Mar 1, 1997·Virchows Archiv : an International Journal of Pathology·M L Hautekeete, A Geerts
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TanakaE Okamoto
Aug 11, 1998·The European Journal of Surgery = Acta Chirurgica·K J PaquetW Ruppert
Jul 27, 2001·Virchows Archiv : an International Journal of Pathology·M IshizakiT Tsuji
Oct 5, 2001·Seminars in Liver Disease·Massimo Pinzani, Fabio Marra
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
Mar 2, 2002·The British Journal of Surgery·W-C LeeM-F Chen
Apr 2, 2002·World Journal of Gastroenterology : WJG·Lun-Xiu Qin, Zhao-You Tang
Aug 6, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Fabio Marra
May 20, 2003·Journal of Gastroenterology and Hepatology·David S R LockwoodDavid C Gotley
Mar 16, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fabio MarraPaolo Gentilini
Nov 19, 2004·Journal of Gastroenterology·Katsuhiko Yanaga
Aug 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timothy M PawlikEddie K Abdalla
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sara AleffiFabio Marra
Jan 6, 2006·The American Journal of Gastroenterology·Claudio ZavagliaGiovambattista Pinzello
Aug 29, 2006·World Journal of Gastroenterology : WJG·Xiao-Ping ChenBi-Xiang Zhang
Mar 9, 2007·World Journal of Surgery·Yong Beom ChoKyung-Suk Suh
Sep 5, 2008·The American Journal of Surgical Pathology·Tomohiro IguchiMasazumi Tsuneyoshi

Related Concepts

Neoplasm Recurrence, Local
Prosthesis Failure
Blood Vessel
Liver Carcinoma
Incidence Studies
Fibrosis, Liver
Vascular Diseases
Neoplasm Invasiveness
Retrospective Studies
Malignant Neoplasm of Liver

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.