Encapsulation of 16-Hydroxycleroda-3,13-Dine-16,15-Olide in Mesoporous Silica Nanoparticles as a Natural Dipeptidyl Peptidase-4 Inhibitor Potentiated Hypoglycemia in Diabetic Mice

Nanomaterials
Po-Kai HuangChing-Feng Weng

Abstract

Natural supplements comprise good efficacy with less adverse effects as against diabetic therapy, but their advancement as anti-diabetic agents is unsatisfactory with regard to the delivery system. Dipeptidyl peptidase-4 (DPP4)/CD26) can degrade glucagon-like pepetide-1 (GLP-1) which renders a decrease of blood glucose levels. 16-hydroxycleroda-3,13-dine-16,15-olide (HCD) extracted from Polyalthia longifolia, exhibits numerous medicinal potentials including hypoglycemic potential. On consideration of HCD application, the bioavailability is affected by low solubility. Extended experiments of anti-diabetic efficacy confirmed HCD biocompatible with mesoporous silica nanoparticles (MSNs) encapsulation resulted in a sustained release property in delivering HCD for the inhibition of DPP4 via the activity and protein levels of DPP4 analysis. In the enzymatic activity assay, MSN-HCD directly changed DPP4 activity. Moreover, MSN-HCD nanoparticles were treated with Caco-2 cells and the protein levels of DPP4 determined within the cells. The results revealed that MSN-HCD caused reduction of DPP4 activity in a time- and dose-dependent fashion. Orally administered MSN-HCD in diet-induced diabetic mice alleviated blood glucose via an oral gl...Continue Reading

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Citations

Jan 30, 2019·International Journal of Molecular Sciences·Po-Kai HuangChing-Feng Weng
Aug 25, 2019·Polymers·Shazia MansoorViness Pillay
Jul 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco Tomás Pérez-DurilloIsabel Prieto
Sep 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jirawat RiyaphanChing-Feng Weng
Sep 23, 2018·International Journal of Molecular Sciences·Feng ZhuFengpei Du
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Feb 20, 2021·Drug Delivery and Translational Research·Senitta StephenBappaditya Chatterjee

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Methods Mentioned

BETA
Assay
chemical extraction
Nuclear magnetic resonance
ELISA
protein assay

Software Mentioned

GraphPad Prism
GraphPad

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