Encapsulation of azithromycin into polymeric microspheres by reduced pressure-solvent evaporation method

International Journal of Pharmaceutics
Xiujuan LiZhenping Wei

Abstract

Azithromycin loaded microspheres with blends of poly-l-lactide and ploy-D,L-lactide-co-glycolide as matrices were prepared by the atmosphere-solvent evaporation (ASE) and reduced pressure-solvent evaporation (RSE) method. Both the X-ray diffraction spectra and DSC thermographs demonstrated that poly-L-lactide existed in a crystalline form in the ASE microspheres, while an amorphous form was present in the RSE formulations. Besides, solvent removal at atmosphere gave microspheres of porous and rough surfaces, but smooth surfaces appeared in the RSE microspheres. The incorporation efficiency as well as the burst release (cumulative release in the first 24h) in the ASE formulations was 39.94 ± 1.18% and 23.96 ± 2.01% respectively, yet the encapsulation efficiency of the microspheres fabricated under 385 mmHg was high up to 57.19 ± 3.81% and the burst release was 4.12 ± 0.15%. The in vitro drug release studies indicated that the ASE microspheres presented a zero-order profile; while the RSE formulations followed first-order kinetics. Other factors including solidification time, temperature, drug to polymer ratio and pH value of the continuous phase could also influence the physicochemical characteristics and release profiles of mic...Continue Reading

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Citations

Oct 15, 2013·Journal of the Science of Food and Agriculture·Fotis SpyropoulosAleksandra K Pawlik
May 7, 2016·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Balakeshwa RamaiahRajarajan Subramanian
Aug 30, 2016·International Journal of Pharmaceutics·Zimeng WangSamantha A Meenach
Sep 8, 2016·Drug Development and Industrial Pharmacy·A Michael Rajesh, Kiritkumar Mangaldas Popat
Apr 11, 2020·Tissue Engineering. Part a·Alexander M Tatara
Feb 28, 2017·Advanced Healthcare Materials·Asha MathewSaso Ivanovski
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Dec 16, 2020·ACS Biomaterials Science & Engineering·Juhi ChakrabortySourabh Ghosh

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