Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

Pharmaceutics
Abul Kalam AzadAbd Almonem Doolaanea

Abstract

Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancient eras. It is one of the most prominent oils used in nutraceutical formulations and daily consumption for its significant therapeutic value is common phenomena. The main aim of this study was to develop alginate-BSO beads as a controlled release system designed to control drug release in the gastrointestinal tract (GIT). Electrospray technology facilitates formulation of small and uniform beads with higher diffusion and swelling rates resulting in process performance improvement. The effect of different formulation and process variables was evaluated on the internal and external bead morphology, size, shape, encapsulation efficiency, swelling rate, in vitro drug release, release mechanism, ex vivo mucoadhesive strength and gastrointestinal tract qualitative and quantitative distribution. All the formulated beads showed small sizes of 0.58 ± 0.01 mm (F8) and spherical shape of 0.03 ± 0.00 mm. The coefficient of weight variation (%) ranged from 1.37 (F8) to 3.93 (F5) ng. All formulations (F1-F9) were studied in vitro for release characteristics and swelling behaviour, then the release data were fitted to various equations to determine...Continue Reading

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Citations

Jul 4, 2020·Drug Development and Industrial Pharmacy·Samah Hamed AlmurisiMd Zaidul Islam Sarker
Aug 25, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Dewi Melani Hariyadi, Nazrul Islam
Oct 27, 2020·Journal of Pharmacy & Bioallied Sciences·Hamzeh AlkhatibAbd Almonem Doolaanea
Oct 30, 2020·International Journal of Nanomedicine·Wisam Nabeel IbrahimAbd Almonem Doolaanea
Jul 9, 2021·International Journal of Biological Macromolecules·Abul Kalam AzadHriday Bera

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Methods Mentioned

BETA
infrared
differential scanning calorimetry
dynamic light scattering
Scanning

Software Mentioned

Expert
Design
Minitab
SpectraGryph
KinetDS
Sigma ScanPro

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