Encapsulation of clozapine in polymeric nanocapsules and its biological effects

Colloids and Surfaces. B, Biointerfaces
Sylwia ŁukasiewiczMarta Dziedzicka-Wasylewska

Abstract

Clozapine is an effective atypical antipsychotic drug that unfortunately exhibits poor oral bioavailability. Moreover, the clinical use of the compound is limited because of its numerous unfavorable and unsafe side effects. Therefore, the aim of the present study was the development of a new nanocarrier for a more effective clozapine delivery. Here, clozapine was encapsulated into polymeric nanocapsules (NCs). Polyelectrolyte multilayer shells were constructed by the technique of sequential adsorption of polyelectrolytes (LbL) using biocompatible polyanion PGA (Poly-L-glutamic acid, sodium salt) and polycation PLL (poly-L-lysine) on clozapine-loaded nanoemulsion cores. Pegylated external layers were prepared using PGA-g-PEG (PGA grafted by PEG (polyethylene glycol)). Clozapine was successfully loaded into the PLL-PGA nanocarriers (CLO-NCs) with an average size of 100 nm. In vitro analysis of the interactions of the CLO-NCs with the cells of the mononuclear phagocytic system (MPS) was conducted. Cell biocompatibility, phagocytosis potential, and cellular uptake were studied. Additionally, the biodistribution and behavioral effects of the encapsulated clozapine were also studied. The results indicate that surface modified (by PEG...Continue Reading

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Citations

Aug 23, 2016·Drug Development Research·Yuan SunLei Song
Jul 28, 2016·Nanotechnology·Krzysztof SzczepanowiczPiotr Warszyński
Sep 6, 2020·Polymers·Joanna Szafraniec-SzczęsnySzczepan Zapotoczny
Feb 5, 2021·Pharmaceutics·Sylwia ŁukasiewiczMarta Dziedzicka-Wasylewska
May 23, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Allan Radaic, Daniel Martins-de-Souza
Mar 18, 2020·The Journal of Physical Chemistry. B·Piotr BatysMaria Sammalkorpi
Oct 4, 2021·Drug Discovery Today·Maria Camilla BergonziElisa Landucci
Nov 6, 2021·Pharmacological Reports : PR·Camila de Oliveira PachecoSandra Elisa Haas

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