Encapsulation of curcumin in diblock copolymer micelles for cancer therapy

BioMed Research International
Ali Mohammad AlizadehMohammad Ali Mohagheghi

Abstract

Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation (P < 0.05). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control (P < 0.05). Average tumor size and weight were significantly lower in PNPC group than control (P < 0.05). PNPC increased proapoptotic Bax protein expression (P < 0.05). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones (P < 0.05). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals (P < 0.05). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Aug 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·Y J WangJ K Lin
Feb 16, 2000·Breast Cancer Research and Treatment·E C MommersJ P Baak
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·A VilaM J Alonso
Sep 6, 2002·Biochemical Pharmacology·Jonathan B Baell, David C S Huang
Apr 7, 2005·Current Cancer Drug Targets·D KarunagaranT R Santhosh Kumar
Aug 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A SharmaW P Steward
Apr 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·James HeyesIan MacLachlan
Apr 19, 2007·Journal of Nanobiotechnology·Savita BishtAnirban Maitra
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jan 15, 2008·Breast Cancer Research : BCR·Stephen B FoxAdrian L Harris
Jul 11, 2009·The AAPS Journal·Jayaraj RavindranBharat B Aggarwal
Aug 12, 2009·International Journal of Pharmaceutics·XiaWei WeiZhiYong Qian
Nov 10, 2009·Breast Cancer Research and Treatment·Madhuri KakaralaMax S Wicha
Aug 16, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Santosh S DhuleRadhika Pochampally
Dec 14, 2011·International Immunopharmacology·Esmaeil BabaeiSeyed Mahmoud Hashemi
Jun 20, 2012·European Journal of Pharmacology·Ali Mohammad AlizadehFarhood Najafi
Sep 8, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N SuwannateepM C Meinke
Jan 23, 2013·BioFactors·Jean-Marc ZinggMohsen Meydani
Sep 21, 2013·European Journal of Pharmacology·Maryam MohsenikiaMohammad Ali Mohagheghi
Feb 18, 2014·International Journal of Nanomedicine·Maryam Tahmasebi MirganiEsmael Babaei
Jul 6, 2014·BioMed Research International·Negar GhalandarlakiSoheil Ashkani-Esfahani

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Citations

Feb 9, 2016·Life Sciences·Maryam MohsenikiaFarhood Najafi
Apr 12, 2015·European Journal of Pharmacology·Baharak FarhangiFarhood Najafi
May 29, 2016·International Journal of Pharmaceutics·Maryam MontazeriNosratollah Zarghami
Jan 27, 2017·Behavioural Pharmacology·Jalaleden NorooziHojjat A Alaei
Jul 22, 2017·Journal of Cellular Biochemistry·Jian Y ZouZhen G Chen
Oct 26, 2018·BioMed Research International·Krzysztof SiemianowiczJarosław Markowski
May 10, 2019·Journal of Gastrointestinal Cancer·Abdolmajid GhasemianMaryam Teimouri
Sep 12, 2019·Pharmaceutical Development and Technology·Juraj MartiskaPetr Jilek
Aug 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sadaf FarsinejadSolmaz Khalighfard
Sep 1, 2015·Cellular Oncology (Dordrecht)·K Vazquez-SantillanV Maldonado
Mar 10, 2021·Biomacromolecules·Yao WangJin Kim Montclare
Mar 27, 2021·Frontiers in Oncology·Alicia S OmbredaneGraziella A Joanitti
May 26, 2021·Drug Development and Industrial Pharmacy·Na QiuGuangxi Zhai

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Methods Mentioned

BETA
Dynamic
atomic force microscopy
AFM

Software Mentioned

SPSS
CCX System

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