Encapsulation of haloalkane 1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazinium in symmetrical α,α',δ,δ'-tetramethyl-cucurbit[6]uril

Physical Chemistry Chemical Physics : PCCP
Xin XiaoJing-Xin Liu

Abstract

Complexation of haloalkane 1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazinium (PZ(+)) dihydrochloride with symmetrical α,α',δ,δ'-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been investigated using NMR spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetry (ITC), and X-ray crystallography. Our data indicate that the chloropropyl group of PZ(+) resides within the cavity of TMeQ[6] in both aqueous solution and the solid state, generating a highly stable inclusion complex PZ(+)@TMeQ[6]. In aqueous solution, the formation of the inclusion complex PZ(+)@TMeQ[6] benefits from the ion-dipole interactions between the guest PZ(+) and the host TMeQ[6]. While in the solid state, hydrogen-bonding interactions also play an important role in stabilizing the inclusion complex PZ(+)@TMeQ[6].

References

Nov 25, 2000·Angewandte Chemie·V BalzaniJ F Stoddart
Dec 20, 2002·Angewandte Chemie·Anthony I DayIan Dance
Aug 20, 2003·Accounts of Chemical Research·Jae Wook LeeKimoon Kim
Mar 12, 2005·Angewandte Chemie·Julius Rebek
Jul 30, 2005·Angewandte Chemie·Jason LagonaLyle Isaacs
Dec 1, 2005·Journal of the American Chemical Society·Simin LiuLyle Isaacs
Jan 17, 2007·Angewandte Chemie·Michael J Frampton, Harry L Anderson
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Mar 27, 2009·Chemical Communications : Chem Comm·Lyle Isaacs
Jul 17, 2009·Accounts of Chemical Research·Julius Rebek
Dec 30, 2009·Journal of the American Chemical Society·Stephen RiethJovica D Badjić
Apr 12, 2011·Accounts of Chemical Research·Fabrizio FabrisOttorino De Lucchi
May 12, 2012·Accounts of Chemical Research·Dariush Ajami, Julius Rebek
Sep 26, 2013·Organic & Biomolecular Chemistry·Yian RuanJovica D Badjić
Dec 7, 2013·Chemistry : a European Journal·Xin XiaoJianzhuang Jiang
Apr 1, 2014·Chemical Society Reviews·Rajesh KumarJong Seung Kim
Jun 14, 2014·Chemical Society Reviews·Keith HermannJovica D Badjić

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.