Encapsulation of Thermo-responsive Gel in pH-sensitive Polymersomes as Dual-Responsive Smart carriers for Controlled Release of Doxorubicin

Journal of Controlled Release : Official Journal of the Controlled Release Society
Fatemeh OroojalianMona Alibolandi

Abstract

In the current study, thermoresponsive poly(N-isopropylacrylamide)-doxorubicin (PNIPAM-DOX) hydrogel was synthesized and loaded into pH-responsive poly ethylene glycol)-2,4,6- trimethoxy benzylidene pentaerythritol carbonate (PEG-PTMBPEC) polymersomes in order to fabricate a smart thermo-pH stimuli responsive drug delivery system. Thermo-pH responsive polymersomal formulation of DOX revealed average size of 170 ± 11.2 nm. The prepared system was loaded with PNIPAM-DOX conjugate with encapsulation efficiency of 30.80%. The in vivo release evaluation demonstrated that the DOX release from polymersomal formulation was pH-dependent, i.e. significantly faster drug release at pH 5.5and 6.5 compared to physiological pH. On the other hand, the drug release rate was significantly decreased at 37 °C due to the gelation of PNIPAM-DOX conjugate in the interior compartment of the pH-responsive polymersomes. The in vivo anti-tumor efficiency of the prepared polymersomal formulation of DOX was evaluated implementing C26 tumor-bearing mice after either intravenous (i.v.) or intratumoral (i.t.) single dose injection. The obtained results demonstrated that the prepared system significantly inhibited tumor growth rate in mice receiving single dos...Continue Reading

Citations

Oct 1, 2019·Combinatorial Chemistry & High Throughput Screening·Samereh GhazanfaryAmirhossein Sahebkar
Jun 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ramesh NandiNadav Amdursky
Oct 3, 2020·Biomaterials Science·Mahsa ShahriariMona Alibolandi
Jul 4, 2020·International Journal of Nanomedicine·Adam KasińskiMarcin Sobczak
Nov 5, 2019·Frontiers in Chemistry·Dao-Yang FanZhong-Jun Liu
Jul 4, 2020·Chemical Communications : Chem Comm·Laís RibovskiInge S Zuhorn
Oct 20, 2020·Advanced Healthcare Materials·Fabio Rizzo, Nermin Seda Kehr
Jul 12, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahsa ShahriariMona Alibolandi
Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
Nov 28, 2020·International Journal of Biological Macromolecules·Tilen KopačAleš Ručigaj
Nov 3, 2020·International Journal of Pharmaceutics·Mahsa ZahiriMona Alibolandi
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fatemeh ArasteMona Alibolandi
Jan 13, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Syuuhei KomatsuAkihiko Kikuchi
Feb 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fatemeh OroojalianMichael R Hamblin
Sep 22, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yibin YuMei Tian
Jun 22, 2021·International Journal of Biological Macromolecules·Maria J M CarneiroRegina C M de Paula
Nov 7, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Seyed Mojtaba Mashmoul MoghadamMohammad Ramezani

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