Encapsulation of vancomycin and gentamicin within cationic liposomes for inhibition of growth of Staphylococcus epidermidis

Journal of Drug Targeting
N M Sanderson, M N Jones

Abstract

Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomycin into such liposomes enhanced its activity relative to the free agent. The effectiveness of the preparation was dependent on the fluidity of the liposomal membrane and on the level of drug entrapment within the aqueous core of the vesicles. The aminoglycoside antibiotic gentamicin was also encapsulated within similar liposomes but was less effective, possibly due to its slow passage through the membrane. The liposomal vancomycin preparation has potential medical use in treating bacterial infections of foreign body biomedical devices (e.g. catheters), with either topical or intravenous administration.

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Citations

Mar 21, 2000·International Journal of Antimicrobial Agents·H Pinto-AlphandaryP Couvreur
Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·S P VyasV Mishra
Jan 29, 2005·Journal of Liposome Research·Hee-Jeong Kim, Malcolm N Jones
Jan 10, 2003·Journal of Liposome Research·Khalid AhmedMalcolm N Jones
Jul 12, 2003·Journal of Liposome Research·Khalid Ahmed, Malcolm N Jones
Jul 15, 2015·Journal of Liposome Research·Marika SuganoMatsuo Yamamoto
May 3, 2008·Journal of Pharmaceutical Sciences·Giulia BonacucinaGiovanni F Palmieri
Feb 9, 2016·Microbial Pathogenesis·Bibi Sedigheh Fazly BazzazShiva Golmohammadzadeh
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ae Jung Huh, Young Jik Kwon
Dec 9, 2009·International Journal of Pharmaceutics·Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach
May 28, 2016·Pharmaceutics·Zora Rukavina, Željka Vanić
Jun 17, 2006·Pharmaceutical Research·Patrick Couvreur, Christine Vauthier
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·C R Dass, T Su
Jun 6, 2021·International Journal of Pharmaceutics·Li DingZhengrong Cui

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