Encapsulation of verapamil and doxorubicin by MPEG-PLA to reverse drug resistance in ovarian cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Weiping ZhengXin Zhan

Abstract

Ovarian cancer is usually treated with transurethral resection or systemic chemotherapy in clinic. However, the development of drug resistance in ovarian cancer is frequently observed in ovarian cancer patients, leading to failure of tumor inhibition and recurrence. In this study, we aimed to efficiently reverse the drug resistance and enhance the anticancer effects by co-delivery of chemotherapeutic agents and multi-drugs resistant proteins inhibitor in ovarian cancer treatment. The cell viability was measured by using MTT or flow cytometry (Annexin V/PI staining) under different culture conditions. Western blot was used to detect the expression of P-gp. We employed confocol to visualize the drug distribution under different culture systems. Using flow cytometry, we examined the drug absorption. MPEG-PLA was used to load chemotherapeutic drugs. We also applied mice model to evaluate the killing ability and side effects of free or methoxy poly (ethylene glycol)-poly (l-lactic acid) (MPEG-PLA) loaded drugs. We found that pre-treatment of verapamil, a multi-drugs resistant proteins inhibitor, could efficiently reverse the drug resistant in ovarian cancer. To further improve the pharmacokinetics profiles and avoid the systemic tox...Continue Reading

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Citations

Aug 15, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christian SecaCiro Isidoro
May 20, 2020·Therapeutic Advances in Medical Oncology·Tianqi SuJiannan Li
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
Jun 3, 2021·Gels·Bibi Noorheen Haleema Mooneerah NeerooaSin-Yeang Teow
May 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shangui LiuGuangxi Zhai
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Piyush Kumar GuptaDillip Kumar Bishi
Jul 22, 2021·The FEBS Journal·Ling WuLiang Zhao

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