PMID: 9637299Jun 24, 1998Paper

Encephalitis in mice inoculated intranasally with an influenza virus strain originated from a water bird

The Journal of Veterinary Medical Science
K ShinyaT Umemura

Abstract

Five-week-old ddY mice were inoculated intranasally with a low virulent (4e) or highly virulent (24a5b) avian influenza virus strain originated from a water bird. None of mice in the 4e group showed clinical signs and brain lesions. Of the 24a5b group, two mice died and one mouse was killed at a moribund state at day 7 post-inoculation (PI). Four mice of the 24a5b group necropsied at day 5 or 7 PI had mild to severe encephalitis in the brain stem and the cerebellar white matter. Influenza virus antigen was detected in neurons, glial cells and vascular endothelium in the lesions. The distribution of the lesions seems to indicate the transneuronal invasion of the virus via cranial nerve fibers into the brain.

References

May 1, 1986·Journal of Virology·V S HinshawR G Webster
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Citations

Mar 1, 2003·Journal of Virology·Aleksandr S LipatovRobert G Webster
Aug 15, 2000·American Journal of Clinical Pathology·J GuarnerS R Zaki
Dec 11, 2003·The Journal of Veterinary Medical Science·Yuji SundenTakashi Umemura
May 11, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·S YokotaM Mori
Sep 3, 2010·Neurocritical Care·Paul Taylor AkinsJames Silverthorn
Mar 24, 2005·The Journal of General Virology·Kazuya MatsudaTakashi Umemura
Nov 13, 2018·Frontiers in Cellular Neuroscience·Karen BohmwaldAlexis M Kalergis

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