Abstract
Previously, we constructed chimeras by injecting hematopoietic cells from experimental autoimmune encephalomyelitis (EAE)-susceptible SJL (H-2s) strain mice into severe combined immunodeficient (SCID) C.B-17scid/scid (H-2d) mice. These SCID mouse-SJL mouse hematopoietic cell chimeras developed passive EAE following adoptive transfer of PLP S139-151-specific SJL T lymphocyte line cells, but were resistant to active EAE induced by primary immunization with PLP S139-151. In order to gain an understanding of the encephalitogenic potential of transplanted hematopoietic progenitors in SCID mouse-SJL mouse chimeras, we attempted to induce EAE in hematopoietic chimeras constructed with or without an additional SJL fetal thymus implant. Chimeras with the thymus implant were susceptible to passive and active EAE while chimeras without the thymus implant were susceptible to passive but not active EAE. Encephalitogenic, CD4+, TCR+ T lymphocytes were selected in vitro from PLP S139-151-immunized, thymus-implanted chimeras. These results showed that hematopoietic SJL progenitors developed into antigen-presenting accessory cells and immunocompetent encephalitogenic T lymphocytes following transplantation into SCID mice. The development of pri...Continue Reading
References
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y SaekiT Kishimoto
Sep 1, 1990·European Journal of Immunology·Y MatsumotoM Fujiwara
Aug 1, 1990·European Journal of Immunology·H TigheD E Mosier
Jul 20, 1990·Journal of Chromatography·E D KatzR Eksteen
Sep 1, 1990·The Journal of Experimental Medicine·M A DuchosalF J Dixon
Jul 1, 1986·Cellular Immunology·H OffnerA A Vandenbark
Jan 1, 1986·Journal of Neuroscience Research·G A HashimE Carvalho
Sep 23, 1988·Science·J M McCuneI L Weissman
Sep 26, 1986·Cell·W SchulerM J Bosma
Jan 15, 1988·Science·W F Hickey, H Kimura
Dec 1, 1987·The Journal of Experimental Medicine·D J HinrichsG N Dietsch
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A BehlkeD Y Loh
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P T MassaA Fontana
Jan 1, 1986·Immunogenetics·R KorngoldP C Doherty
Apr 1, 1985·Journal of Neuroimmunology·U TraugottC S Raine
Jan 1, 1985·Journal of Cellular Biochemistry·B A StandageD R Burger
Oct 1, 1973·The Journal of Experimental Medicine·R M Williams, M J Moore
Oct 1, 1983·The Journal of Experimental Medicine·S Sriram, L Steinman
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A LaursenM B Lees
Feb 10, 1983·Nature·G C BosmaM J Bosma
Jun 1, 1993·Journal of Neuroscience Research·R H WhithamH Offner
Jul 1, 1993·Annals of Neurology·G MartinoL M Grimaldi
Citations
Feb 1, 1996·Immunological Reviews·H WekerleK Kojima
Jul 9, 1998·Journal of Neuroimmunology·J A LyonsR B Fritz
Jun 23, 1999·Journal of Neuroimmunology·R E JonesD N Bourdette