Encephalopathy and Axonal Neuropathy Associated With Mycoplasma Pneumoniae Infection: Response to Intravenous Immunoglobulin Therapy

Child Neurology Open
Ali SakerHusn Frayha

Abstract

Mycoplasma pneumoniae infection frequently presents as a self-limited process, however, severe cases and even fatalities have been reported. The authors present a case of Mycoplasma pneumoniae infection associated with both encephalopathy and peripheral neuropathy that responded to intravenous immunoglobulin therapy. To our knowledge, this is the first documented case of Mycoplasma pneumoniae related to encephalitis and peripheral axonal neuropathy. To date, there is insufficient data on the effect of intravenous immunoglobulin on the course of mycoplasma-associated central nervous system/peripheral nervous system disease. While intravenous immunoglobulin has aided in a variety of autoimmune-mediated disorders, its efficacy in mycoplasma-mediated encephalitis treatment remains unclear. In this patient case, reversal of both central and peripheral nervous system symptoms after treatment with intravenous immunoglobulin suggested a possible therapeutic benefit.

References

Sep 1, 1989·The Pediatric Infectious Disease Journal·E Lehtokoski-Lehtiniemi, M L Koskiniemi
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Koskiniemi
Oct 17, 1998·Journal of Clinical Microbiology·M E WarisO Ruuskanen
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A BitnunS Richardson
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A GlaserJ H Tureen
Aug 3, 2007·Pediatrics·Laura J ChristieCarol A Glaser
May 29, 2008·European Journal of Pediatrics·Uluç YişEray Dirik

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Axonal Neuropathies

Axonal Neuropathy refers to disease or dysfunction of nerves caused as a result of damage or degeneration of axons. Here is the latest research.