A growing number of studies are revealing that cells can send and receive information by controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we discuss what is known about the dynamics of various signaling networks and their role in controlling cellular responses. We identify general principles that are emerging in the field, focusing specifically on how the identity and quantity of a stimulus is encoded in temporal patterns, how signaling dynamics influence cellular outcomes, and how specific dynamical patterns are both shaped and interpreted by the structure of molecular networks. We conclude by discussing potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease.
Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.
Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks.
Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling
Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.
An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.
Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts
High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations
Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs
Energetic modeling and single-molecule verification of dynamic regulation on receptor complexes by actin corrals and lipid raft domains
Translatome analyses capture of opposing tissue-specific brassinosteroid signals orchestrating root meristem differentiation
Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data
Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling
Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
In silico model-based inference: an emerging approach for inverse problems in engineering better medicines
Blm-s, a BH3-only protein enriched in postmitotic immature neurons, is transcriptionally upregulated by p53 during DNA damage
Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
Calcium & Bioenergetics
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.
Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.