Encoding biological recognition in a bicomponent cell-membrane mimic

Proceedings of the National Academy of Sciences of the United States of America
Cesar Rodriguez-EmmeneggerVirgil Percec

Abstract

Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same periodic and quasiperiodic arrays were subsequently found in block copolymers, surfactants, lipids, glycolipids, and other complex molecules. Here we report the discovery of lamellar and hexagonal periodic arrays on the surface of vesicles generated from sequence-defined bicomponent monodisperse oligomers containing lipid and glycolipid mimics. These vesicles, known as glycodendrimersomes, act as cell-membrane mimics with hierarchical morphologies resembling bicomponent rafts. These nanosegregated morphologies diminish sugar-sugar interactions enabling stronger binding to sugar-binding proteins than densely packed arrangements of sugars. Importantly, this provides a mechanism to encode the reactivity of sugars via their interaction with sugar-binding proteins. The observed sugar phase-separated hierarchical arrays with lamellar and hexagonal morphologies that encode biological recognition are among the most complex archi...Continue Reading

References

Nov 5, 1988·Journal of Molecular Biology·P MarianiH Delacroix
Feb 18, 1972·Science·S J Singer, G L Nicolson
Mar 28, 2001·Science·C R Bertozzi, L L Kiessling
Mar 30, 2002·Science·Jean-Marie Lehn
Feb 22, 2003·Science·Goran UngarWook-Dong Cho
Mar 12, 2004·Nature·Xiangbing ZengJamie K Hobbs
Aug 13, 2004·Nature·Virgil PercecSergei A Vinogradov
Jun 28, 2006·The Journal of Physical Chemistry. B·Lydia PaccamiccioPaolo Mariani
Apr 27, 2007·Nature·Peter H Seeberger, Daniel B Werz
Sep 6, 2007·Journal of the American Chemical Society·Mark S KaucherVirgil Percec
Dec 22, 2007·Chemical Reviews·Philip Ball
May 21, 2008·Journal of the American Chemical Society·Virgil PercecPaul A Heiney
Jul 26, 2008·Nature Nanotechnology·Ben L Feringa, Wesley R Browne
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Mar 25, 2009·Journal of the American Chemical Society·Virgil PercecPaul A Heiney
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Oct 16, 2010·Science·Mihai Peterca, Virgil Percec
Aug 3, 2011·Biophysical Journal·Margarida BastosDaniela Uhríková
Nov 10, 2011·Journal of the American Chemical Society·Mihai PetercaAnnabelle Bertin
Apr 28, 2012·Science·Frank S BatesGlenn H Fredrickson
Jul 28, 2012·Science·Pablo F DamascenoSharon C Glotzer
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Sep 13, 2012·Analytical and Bioanalytical Chemistry·Sandrine MorandatKarim El Kirat
Feb 7, 2013·Biochimica Et Biophysica Acta·Tânia SilvaMargarida Bastos
Feb 9, 2013·Journal of the American Chemical Society·Frederick A HeberleJohn Katsaras
Feb 20, 2013·Angewandte Chemie·Jean-Marie Lehn
Apr 10, 2013·Journal of the American Chemical Society·Eva Maria MunozEduardo Fernandez-Megia
Apr 25, 2014·Journal of the American Chemical Society·Cécile RocheVirgil Percec
Oct 18, 2014·Chemical Society Reviews·Hao-Jan SunVirgil Percec
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shaodong ZhangVirgil Percec
Sep 29, 2015·Journal of the American Chemical Society·Jonathan D NickelsJohn Katsaras
Oct 13, 2015·Macromolecular Rapid Communications·Matthias Schulz, Wolfgang H Binder
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Qi XiaoVirgil Percec
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Qi XiaoVirgil Percec
Apr 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Timothy M GillardFrank S Bates
Sep 1, 2016·Journal of the American Chemical Society·Qi XiaoVirgil Percec
Nov 1, 2016·Nature Materials·Xingchen YeChristopher B Murray

❮ Previous
Next ❯

Citations

Jul 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Paola TorreVirgil Percec
May 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Qi XiaoVirgil Percec
Aug 9, 2020·Chemical Society Reviews·Yuanyuan WeiKen-Tye Yong
Apr 7, 2021·Plant Physiology·Rosa L López-MarquésMichael Palmgren
Jul 30, 2021·Journal of the American Chemical Society·Dapeng ZhangVirgil Percec
Sep 19, 2019·Journal of the American Chemical Society·Benjamin E PartridgeVirgil Percec
May 21, 2020·Journal of the American Chemical Society·Zhongwei SunShaodong Zhang
Jul 16, 2019·Nano Letters·Nina Yu KostinaCesar Rodriguez-Emmenegger
Oct 22, 2021·Journal of the American Chemical Society·Dapeng ZhangVirgil Percec

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
atomic force microscopy
AFM
biosensors
transmission electron microscopy

Software Mentioned

UV Probe
Gwyddion
Accelrys Discovery Studio
Accelrys DS ViewerPro
Chem3D
Shimadzu

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.