Encoding of a homolog of the IFN-gamma receptor by myxoma virus

Science
C UptonGrant McFadden

Abstract

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-gamma). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-gamma and inhibits the biological activity of extracellular IFN-gamma, one of the key regulatory cytokines in the host immune response against viral infections.

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Related Concepts

M-T7 protein, Myxoma virus
Metazoa
Genes, Viral
Interferon Type II
Myxoma virus
Plasma Protein Binding Capacity
Chinchilla Rabbits
Viral Interference
Viral Proteins
Restriction Mapping

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