Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-gamma). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-gamma and inhibits the biological activity of extracellular IFN-gamma, one of the key regulatory cytokines in the host immune response against viral infections.
From trypanosomes to the nervous system, from molecules to behavior: a survey, on the occasion of the 90th anniversary of Castellani's discovery of the parasites in sleeping sickness
Interferon induction in peripheral blood mononuclear leukocytes of man and farm animals by poxvirus vector candidates and some poxvirus constructs
Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967
Myxoma virus as a vaccine vector for rabbits: antibody levels to influenza virus haemagglutinin presented by a recombinant myxoma virus
Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus
Defining the anti-inflammatory activity of a potent myxomaviral chemokine modulating protein, M-T7, through site directed mutagenesis
Smallpox infections during pregnancy, lessons on pathogenesis from nonpregnant animal models of infection
A pox on thee! Manipulation of the host immune system by myxoma virus and implications for viral-host co-adaptation
A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily
Was exposure to directly antiviral cytokines during primary infection an important selective pressure in the evolution of unique immune evasion strategies by viruses?
Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models
Variation in host susceptibility and infectiousness generated by co-infection: the myxoma-Trichostrongylus retortaeformis case in wild rabbits
Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections
An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain
Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response
Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action
Vaccinia virus vectors with an inactivated gamma interferon receptor homolog gene (B8R) are attenuated In vivo without a concomitant reduction in immunogenicity
Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model
Human parainfluenza virus type 3 inhibits gamma interferon-induced major histocompatibility complex class II expression directly and by inducing alpha/beta interferon
Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection
The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury
Detection of myxoma viruses encoding a defective M135R gene from clinical cases of myxomatosis; possible implications for the role of the M135R protein as a virulence factor
Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection
A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference
Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells
Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue
Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel mechanism for evasion of host defense
Construction and evaluation of live attenuated myxoma virus vaccines with targeted virulence gene deletions
Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway
The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses
New strategies for chemokine inhibition and modulation: you take the high road and I'll take the low road
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues
The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory protein
Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M-T1, during myxoma virus pathogenesis
Functional comparisons among members of the poxvirus T1/35kDa family of soluble CC-chemokine inhibitor glycoproteins
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors
Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis
Coevolution of host and virus: the pathogenesis of virulent and attenuated strains of myxoma virus in resistant and susceptible European rabbits
Coevolution of host and virus: cellular localization of virus in myxoma virus infection of resistant and susceptible European rabbits
Identification of residues in an orthopoxvirus interleukin-18 binding protein involved in ligand binding and species specificity
Myxoma virus and Shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability
Mapping and investigation of the role in pathogenesis of the major unique secreted 35-kDa protein of rabbitpox virus
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication
MSLVP: prediction of multiple subcellular localization of viral proteins using a support vector machine
Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor
The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists
Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses
Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimer that each bind rabbit TNFalpha, but the dimer is a more potent TNF inhibitor
Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling
The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication
The gammaherpesvirus chemokine binding protein can inhibit the interaction of chemokines with glycosaminoglycans
The myxoma virus-soluble interferon-gamma receptor homolog, M-T7, inhibits interferon-gamma in a species-specific manner
Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection
Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation
Functional analysis of the human cytomegalovirus US28 gene by insertion mutagenesis with the green fluorescent protein gene
Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA
Recombinant Myxoma Virus -Derived Immune Modulator M-T7 Accelerates Cutaneous Wound Healing and Improves Tissue Remodeling
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
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Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
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STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.