Encoding of compressive stress during indentation by slowly adapting type I mechanoreceptors in rat hairy skin

Journal of Neurophysiology
W Ge, P S Khalsa

Abstract

The mechanical state encoded by slowly adapting type 1 mechanoreceptors (SAI) during indentation was examined using an isolated preparation in a rat model. Skin and its intact innervation were harvested from the medial thigh of the rat hindlimb and placed in a dish, with the corium side down, containing synthetic interstitial fluid. The margins of the skin were coupled to an apparatus that could stretch and apply compression to the skin. Using a standard teased nerve preparation, the neural responses of single SAIs were identified. SAIs were stimulated, using controlled compressive stress while simultaneously measuring displacement, by compressing the skin between indenters (flat cylinders) of different diameters and a hard platform. SAIs were subcategorized according to whether their neural response saturated above or below 10 kPa compressive stress (SAI-H or SAI-L, respectively). Linear regression was used to evaluate the relationships between neuron response and stress and force and displacement. For all SAIs, the mean neural response was significantly and substantially more highly correlated with compressive stress than force or displacement. For the SAI-L subcategory, the mean correlation coefficient was significantly and ...Continue Reading

References

Jan 1, 1992·Annual Review of Neuroscience·K O Johnson, S S Hsiao
Jun 1, 1991·Journal of Neurophysiology·M S FullerA H Hoffman
Nov 1, 1988·The Journal of the Acoustical Society of America·S J BolanowskiC M Checkosky
Feb 1, 1969·The Journal of Physiology·A Iggo, A R Muir
May 1, 1984·Experimental Neurology·J Leon, A J McComas
Apr 1, 1984·Journal of Neurophysiology·S J Bolanowski, J J Zwislocki
Jun 1, 1982·Journal of Neurophysiology·A Rossi, P Grigg
May 1, 1994·Canadian Journal of Physiology and Pharmacology·R H LaMotteA Klusch-Petersen
Feb 1, 1996·Journal of Biomechanical Engineering·M A Srinivasan, K Dandekar
Jul 1, 1996·Journal of Neurophysiology·P S KhalsaP Grigg
Nov 1, 1996·Journal of Neurophysiology·P Grigg
Jul 1, 1997·Journal of Neurophysiology·P S KhalsaP Grigg
Oct 27, 1997·Journal of Neurophysiology·M KoltzenburgG R Lewin
Aug 15, 1998·Journal of Neurophysiology·Z D Prete, P Grigg
Aug 6, 1926·The Journal of Physiology·E D Adrian, Y Zotterman

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Citations

Feb 17, 2006·Journal of Neurophysiology·Arun P SripatiKenneth O Johnson
Jul 5, 2016·Nature Materials·Alex ChortosZhenan Bao
Feb 5, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Partap S Khalsa
Nov 10, 2016·Cell Reports·Kara L MarshallEllen A Lumpkin
Feb 19, 2016·Journal of the Royal Society, Interface·Benoit DelhayeJean-Louis Thonnard
Jul 22, 2004·Muscle & Nerve·Partap S Khalsa, Weiqing Ge
Mar 18, 2008·Somatosensory & Motor Research·Gregory J Gerling, Geb W Thomas
Mar 4, 2003·Journal of Neurophysiology·Zaccaria Del PretePeter Grigg

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