Encoding of Sucrose's Palatability in the Nucleus Accumbens Shell and Its Modulation by Exteroceptive Auditory Cues

Frontiers in Neuroscience
Miguel VillavicencioRanier Gutierrez

Abstract

Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory stimulus affects sucrose palatability and, in the NAcSh, the neuronal correlates of this behavior. To address these questions in behaving rats, we investigated how food-related auditory cues modulate sucrose's palatability. The goals are to determine whether NAcSh neuronal responses would track sucrose's palatability (as measured by the increase in hedonically positive oromotor responses lick rate), sucrose concentration, and how it processes auditory information. Using brief-access tests, we found that sucrose's palatability was enhanced by exteroceptive auditory cues that signal the start and the end of a reward epoch. With only the start cue the rejection of water was accelerated, and the sucrose/water ratio was enhanced, indicating greater palatability. However, the start cue also fragmented licking patterns and decreased caloric intake. In the presence of both start and stop cues, the animals fed continuously a...Continue Reading

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Citations

Nov 20, 2018·ELife·Esmeralda FonsecaRanier Gutierrez
Mar 9, 2019·Frontiers in Neuroscience·Leopoldo Emmanuel Polo-CastilloAlberto Caballero-Ruiz
Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Ranier GutierrezSidney A Simon
Mar 15, 2019·Scientific Reports·Paul FranckeStefanie Brassen
Oct 21, 2018·Nature Communications·David OttenheimerPatricia H Janak
Nov 12, 2020·Journal of Neurophysiology·Katherine N Wright, Daniel W Wesson
Feb 9, 2021·Frontiers in Neuroscience·Aketzali GarciaRanier Gutierrez

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