PMID: 9421515Feb 28, 1998Paper

End effects in DNA recognition by zinc finger arrays

Nucleic Acids Research
Y Choo

Abstract

The paradigmatic DNA binding domain from the transcription factor Zif268 contains three zinc finger modules in tandem repeat. When bound to their cognate DNA site the fingers read out the sequence of one DNA strand by making a linear series of successive base contacts. It is shown that the base-specific protein-DNA contacts made from the ends of the Zif268 three-finger array contribute less to the stability of the intermolecular complex than do structurally equivalent contacts from more central regions of the DNA binding domain. The effect is akin to the end fraying observed in duplex nucleic acid molecules.

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Citations

Dec 7, 2002·Bioorganic & Medicinal Chemistry·Keizo Matsushita, Yukio Sugiura
Jun 8, 2001·Annual Review of Biochemistry·C O PaboR A Grant
Feb 14, 2014·Nucleic Acids Research·Ankit GuptaGary D Stormo
Apr 28, 2009·Advanced Drug Delivery Reviews·Takashi Sera
Mar 1, 2015·The International Journal of Biochemistry & Cell Biology·Yu SongJianguo Wu
Jan 27, 1999·Biochemical and Biophysical Research Communications·N CorbiC Passananti
Mar 18, 2000·The Journal of Biological Chemistry·J S Kang, J S Kim
Nov 25, 2005·Journal of the American Chemical Society·Akira OnodaTakeshi Yamamura

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