End Functionalized Nonionic Water-Dispersible Conjugated Polymers

Macromolecular Rapid Communications
Ruoyu Zhan, Bin Liu

Abstract

2,7-Dibromofluorene monomers carrying two or four oligo(ethylene glycol) (OEG) side chains are synthesized. Heck coupling between the monomers and 1,4-divinylbenzene followed by end capping with [4-(4-bromophenoxy)butyl]carbamic acid tert-butyl ester leads to two nonionic water-dispersible poly(fluorene-alt-1,4-divinylenephenylene)s end-functionalized with amine groups after hydrolysis. In water, the polymer with a lower OEG density (P1) has poor water dispersibility with a quantum yield of 0.24, while the polymer with a higher OEG density (P2) possesses excellent water-dispersibility with a high quantum yield of 0.45. Both polymers show fluorescence enhancement and blue-shifted absorption and emission maxima in the presence of surfactant sodium dodecyl sulfate and dodecyltrimethylammonium bromide. The polymers are also resistant to ionic strength with minimal nonspecific interactions to bovine serum albumin. When biotin is incorporated into the end of the polymer backbones through N-hydroxysuccinimide/amine coupling reaction, the biotinylated polymers interact specifically with streptavidin on solid surface.

References

Jun 27, 1990·Journal of Chromatography·E A Bayer, M Wilchek
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·L ChenD G Whitten
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Deli WangAlan J Heeger
Aug 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brent S GaylordGuillermo C Bazan
Mar 4, 2003·Chemical Communications : Chem Comm·Kenichi Kuroda, Timothy M Swager
Aug 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·K Peter R NilssonOlle Inganäs
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mauricio R Pinto, Kirk S Schanze
Aug 11, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ik-Bum KimUwe H F Bunz
Mar 28, 2007·Chemical Reviews·Samuel W ThomasTimothy M Swager
Apr 10, 2007·The International Journal of Biochemistry & Cell Biology·Rolf I Skotheim, Matthias Nees
May 14, 2008·Journal of the American Chemical Society·Ronnie L PhillipsUwe H F Bunz
Sep 10, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Imre VargaTibor Gilányi
Jun 24, 2010·Chemical Society Reviews·Alan J Heeger
Jul 15, 2011·Journal of the American Chemical Society·Christopher A TrainaGuillermo C Bazan
Mar 2, 1998·Angewandte Chemie·Arno KraftAndrew B Holmes

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