PMID: 8939714Nov 1, 1996Paper

End of the line: proteolytic degradation of cyclin-dependent kinase inhibitors

Chemistry & Biology
R J Sheaff, J M Roberts

Abstract

Cyclin-dependent kinase inhibitors (CKIs) are crucial regulators of cell-cycle progression. The CKI Sic1 controls the timing of DNA replication by inhibiting Clb-Cdc28 kinase. Phosphorylation of Sic1 by CIn-Cdc28 kinase alleviates this inhibition by targeting Sic1 for degradation through the ubiquitin-mediated proteolytic pathway.

References

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May 15, 1995·Genes & Development·C J Sherr, J M Roberts
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Citations

May 27, 1999·Health Care Analysis : HCA : Journal of Health Philosophy and Policy·R Sheaff
May 23, 2002·Genes & Development·Zhongsheng YouJohn Newport
Jul 5, 2016·Cell Reports·Catherine JohnsonTakashi Kubota
Mar 4, 2015·Molecular and Cellular Biology·Alberto González-NovoFrancesc Posas
Jan 1, 1997·Biopolymers·M BogyoH L Ploegh

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