PMID: 1203859Dec 1, 1975Paper

End results of radiation therapy, alone and combination with 5-fluorouracil in colorectal cancers

Cancer
V VongtamaJ H Webster

Abstract

The authors retrospectively analyzed the results of irradiation in 148 cases of primary inoperable and recurrent adenocarcinoma of the colon and rectum treated at the Department of Radiation Therapy, Roswell Park Memorial Institute between 1962 and 1970. This group includes 95 recurrences and 53 inoperable primaries. Uninterrupted radiotherapy was used in 118 cases and split-course technique in 30 cases. Eleven patients received combined radiotherapy and surgery. Seventy-eight patients received a combination of 5-fluorouracil (5-FU) and irradiation. The response rate and survival of individual groups is discussed in detail. This study indicated that perineal recurrences should receive whole pelvic irradiation in addition to perineum field. Split-course technique appeared to yield a better survival than the uninterrupted course. The best 5-year survival rate (64%) is found in the group treated with a combination of radiation and surgery. For locally advanced, inoperable cancers, split-course technique, combined 5-FU and irradiation gave the best results, achieving longer palliation with improved quality of life and sometimes yielding cure (5-year survival).

References

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Citations

Dec 1, 1985·Diseases of the Colon and Rectum·W Dobrowsky, A P Schmid
Jul 1, 1982·International Journal of Radiation Oncology, Biology, Physics·T HabeshawJ Kirk
Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·C S WongY Hao
Feb 1, 1992·The British Journal of Radiology·W Dobrowsky
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·W RhombergB Schneider
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C S WongC N Catton
Oct 1, 1987·Medicinal Research Reviews·K T Douglas
Apr 16, 1998·Seminars in Radiation Oncology·C S Wong, J D Brierley
Oct 1, 1995·The British Journal of Surgery·G GagliardiS J Arnott
Jan 1, 1982·Acta Radiologica. Oncology·S Ciatto, P Pacini
Jan 1, 1982·Acta Radiologica. Oncology·H von der MaaseT Sveinsson

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