PMID: 11560788Sep 19, 2001Paper

End-stage Liver Disease in Children

Current Treatment Options in Gastroenterology
Robert Squires


The treatment of children with end-stage liver disease involves the coordinated management of nutritional deficiencies, ascites, pruritus, encephalopathy, and portal hypertension. The implementation of management strategies depends upon a parent or guardian to administer the plan in the context of a child at different stages of developmental, physiologic, emotional, and physical maturity. Fat-soluble vitamins (A, D, E, and K) and micronutrient levels should be monitored routinely and supplemented if deficient. In some patients, supplemental nutrition to provide additional energy and protein is needed to ensure optimal growth and development. Ascites often respond to spironolactone and sodium restriction, but may require the addition of a loop diuretic or even abdominal paracentesis. Pruritus significantly impairs the quality of life of patients and is typically treated with ursodeoxycholic acid, rifampin, or an antihistamine. Partial biliary diversion, or liver transplant in some instances, is necessary for patients with self-mutilating pruritus that results from intrahepatic cholestasis. Hepatic encephalopathy is poorly defined in infants and small children. Elevated serum ammonia serves as a surrogate marker for encephalopath...Continue Reading


Apr 8, 1976·The New England Journal of Medicine·F R Smith, D S Goodman
Dec 16, 1992·JAMA : the Journal of the American Medical Association·E A Jones, N V Bergasa
Nov 1, 1991·Gut·C O Record
Feb 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·L A MorenoJ P Farriaux
Jan 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·R ProujanskyS A Kocoshis
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E A Jones, N V Bergasa
Apr 1, 1990·Gastroenterology·H A CynamonR P Iafrate
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C BucuvalasN E Vieira
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HeubiR C Tsang
Jul 1, 1987·European Journal of Pediatrics·R H HouwenC M Bijleveld
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O Amédée-ManesmeJ A Olson
Feb 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·V L FoxA M Leichtner
Mar 1, 1997·Journal of Pediatric Surgery·A ShunM Stephen
Aug 14, 1997·The New England Journal of Medicine·S M Riordan, R Williams
Aug 1, 1997·Journal of Hepatology·R I HoltJ P Miell
Jan 1, 1997·Seminars in Liver Disease·B A Runyon
Nov 14, 1997·Lancet·R Jalan, P C Hayes
Apr 2, 1998·Journal of Pediatric Gastroenterology and Nutrition·C SiafakasS Nurko
Feb 18, 1999·Journal of Pediatric Surgery·J ReyesS Kocoshis

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Mar 5, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Praveen Sharma, Barjesh C Sharma
May 13, 2008·Gastroenterology·Mike A Leonis, William F Balistreri
Sep 5, 2006·Pediatrics·Laura P JamesUNKNOWN Pediatric Acute Liver Failure Study Group

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