Endemic fungal infections caused by Cryptococcus neoformans and Penicillium marneffei in patients infected with human immunodeficiency virus and treated with highly active anti-retroviral therapy

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
H-Y SunS C Chang

Abstract

This study compared the clinical presentations of 58 episodes of cryptococcosis in 50 patients and 26 episodes of penicillosis in 25 patients infected with human immunodeficiency virus (HIV) between June 1994 and June 2004, and assessed the safety of discontinuation of secondary prophylaxis for endemic fungal infections in those patients responding to highly active anti-retroviral therapy (HAART). Neurological symptoms were seen more commonly in patients with cryptococcosis, whereas respiratory symptoms, lymphadenopathy, hepatomegaly and/or splenomegaly, and non-thrush-related oral presentations were seen more commonly in patients with penicillosis. Patients with penicillosis were more likely to have abnormal chest radiography results and radiographic presentations of interstitial lesions, cavitations, fibrotic lesions and mass lesions. At the end of the study, maintenance antifungal therapy had been discontinued in 27 patients with cryptococcosis and in 18 patients with penicillosis in whom the median CD4 count had increased to 186 cells/microL (range, 9-523 cells/microL) and 95 cells/microL (range, 15-359 cells/microL), respectively, after HAART. Only one episode of penicillosis recurred (a relapse rate of 1.72/100 person-yea...Continue Reading

References

Jul 9, 1994·Lancet·K SupparatpinyoT Sirisanthana
Apr 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E Gallant, A H Ko
Aug 8, 1998·The New England Journal of Medicine·S H MichaelsP Kissinger
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R GraybillW Dismukes
Apr 20, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanJ L Jones
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Asda VibhagoolAtiporn Ingsathit
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Feb 7, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cristina MussiniUNKNOWN International Working Group on Cryptococcosis
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mitchell GoldmanUNKNOWN AIDS Clinical Trials Group A5038 Study Group

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Citations

Dec 27, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julie R HarrisHenry C Baggett
Apr 7, 2007·Current Opinion in Pulmonary Medicine·Alejandro Sanchez, Robert Larsen
Feb 12, 2009·HIV Medicine·C-Y LinS-C Chang
Apr 11, 2008·Clinical Microbiology Reviews·L Beth Gadkowski, Jason E Stout
Feb 19, 2011·Pathology Research International·Stephenie Y N Wong, K F Wong
Sep 21, 2013·ISRN AIDS·Spinello Antinori
Nov 14, 2014·Médecine et maladies infectieuses·V T SonM Strobel
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yi-Chien LeeYee-Chun Chen
May 23, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Hung LiaoJen-Hsian Wang
Mar 23, 2013·Oral Diseases·L L PattonK Ranganathan
Jan 15, 2008·Current Opinion in Infectious Diseases·Andrew P UstianowskiJeremy N Day
Mar 25, 2008·Therapeutics and Clinical Risk Management·Javier PemánMiguel Gobernado
May 23, 2015·Archives of Endocrinology and Metabolism·Guilherme Almeida Rosa da SilvaRogerio Neves Motta
May 8, 2018·Indian Journal of Medical Microbiology·Rachita DhuratAnand Kumar

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