Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases

Annals of Neurology
J C VernantG de-Thé

Abstract

Tropical spastic paraparesis (TSP) is a common myeloneuropathy with primary and predominant involvement of the pyramidal tract and minimal sensory loss. The epidemic form of TSP is related to toxic nutritional factors, but the endemic form occurs in clusters in tropical areas, especially in India, Africa, the Seychelles, Colombia, and areas of the Caribbean. We describe the clinical and epidemiological features of 25 TSP patients from Martinique (French West Indies) with serum antibodies to human T-lymphotropic virus type I (HTLV-I). Furthermore, all 11 patients who were seropositive for HTLV-I had specific HTLV-I antibodies in their CSF. All were women. The age of onset varied from 25 to 60 years (mean, 45 years). The main clinical features are spastic paraparesis or paraplegia with spasticity of the upper limbs, minimal sensory loss, and bladder dysfunction. Minimal estimated incidence and prevalence are 1 per 100,000 inhabitants per year and 8 per 100,000, respectively. Seventeen percent of the relatives of patients with HTLV-I-associated TSP have HTLV-I antibodies (1 husband and 7 children). In Martinique, the prevalence of HTLV-I antibodies in the general population is about 2% and reaches 10% for neurological disorders ot...Continue Reading

References

Oct 3, 1985·Nature·F Wong-Staal, R C Gallo
Sep 14, 1985·Lancet·W A SheremataM E Whiteside
Nov 30, 1985·Lancet·P Rodgers-JohnsonD S Graham
Apr 5, 1986·Lancet·P Rodgers-JohnsonD S Graham
May 3, 1986·Lancet·M OsameM Tara
Aug 1, 1985·Neurology·G RománB S Schoenberg
Nov 14, 1985·Nature·H KoprowskiR C Gallo
May 30, 1986·Science·D M Barnes
Dec 1, 1987·American Family Physician·D B Clifford
Mar 1, 1985·International Journal of Epidemiology·A P LanierJ F Wilson
Apr 1, 1985·Annals of Neurology·G RománB S Schoenberg
Jul 1, 1969·Journal of the Neurological Sciences·K S ManiR D Montgomery
Nov 15, 1984·International Journal of Cancer. Journal International Du Cancer·L Schaffar-DeshayesJ P Levy
Aug 1, 1983·Annals of Neurology·P M Moore, T R Cupps
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Feb 1, 1984·Annals of Neurology·A HaaseN Nathanson
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Sep 1, 1964·Brain : a Journal of Neurology·R D MontgomeryW H MCMENEMEY

Citations

Feb 1, 1990·Annals of Neurology·S JacobsonD McFarlin
Jan 1, 1991·Annals of Neurology·D S YoungerJ Powers
Dec 1, 1990·Journal of Neuroscience Research·S U Kim
Jan 1, 1988·Journal of Neurology·T YokotaH Tsukagoshi
Dec 1, 1991·Chromosoma·D Taruscio, L Manuelidis
Apr 1, 1994·Molecular Neurobiology·O St Clair Morgan
Oct 1, 1988·Journal of the Neurological Sciences·H ShibasakiS Komine
Sep 1, 1991·Journal of the Neurological Sciences·Y KurodaF Nagumo
Dec 1, 1991·Journal of the Neurological Sciences·Y Kuroda, H Sugihara
Oct 1, 1995·Journal of the Neurological Sciences·Y KurodaM Matsui
Nov 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·R D Montgomery
Jul 28, 1990·Lancet·K KazadiG de-Thé
Oct 12, 1991·Lancet·S HyerS S Nussey
Nov 21, 1987·Lancet·M SugimotoS Kawasaki
Aug 15, 1987·Lancet·J C VernantG Román
Jun 1, 1997·Blood Reviews·O C FerreiraJ D Rosenblatt
Apr 1, 1991·Transfusion Medicine Reviews·S G SandlerA E Williams
Dec 20, 1999·Transfusion Medicine Reviews·A M CouroucéC Saura
Apr 1, 1993·Epidemiology and Infection·S NightingaleU Desselberger
Sep 13, 1990·The New England Journal of Medicine·E F Salazar-GruesoR P Roos
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y PaquetteP Jolicoeur
Mar 1, 1991·AIDS Research and Human Retroviruses·D M AboulafiaD J Slamon
Jul 1, 1992·AIDS Research and Human Retroviruses·G A DekabanG P Rice
Feb 1, 1992·AIDS Research and Human Retroviruses·R E KoenigC Amoros
May 11, 1992·AIDS Research and Human Retroviruses·J M TrujilloC Arango
Jun 14, 2003·The Neurologist·R B KhanM C Levin
Mar 15, 2006·The Neurologist·Hideaki MatsuiNobuyuki Oka
Jan 1, 1990·Vox Sanguinis·B HjelleS Swenson
Apr 1, 1991·Brain Pathology·F Chiodi, E M Fenyö
Jan 1, 1997·Brain Pathology·F Scaravilli
Aug 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·R KakigiK Hashimoto
Jan 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·K KayembeH Carton
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·A OgataC Mikuni
Apr 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·P CabreC R Newton
Apr 5, 2007·Retrovirology·Nicola J Rose, Andrew M L Lever
Feb 16, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Mitsuaki Yoshida
Apr 1, 1994·European Journal of Epidemiology·A C de AraujoL Chieco-Bianchi
Sep 19, 2007·International Journal of Hematology·Yorifumi Satou, Masao Matsuoka
Sep 19, 2007·International Journal of Hematology·Mari Kannagi
Jul 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G PerezJ J Bourgoignie
May 1, 1989·Mayo Clinic Proceedings·M Rodriguez
Jun 25, 2015·Journal of Clinical and Experimental Hematopathology : JCEH·Satsuki OwatariShuichi Hanada
Nov 1, 1989·Acta Neurologica Scandinavica·S Kam-HansenS Baig
Feb 1, 1987·Annals of Neurology·R T Johnson, J C McArthur
Sep 21, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Romain DeschampsS Olindo
Oct 31, 2012·Progress in Retinal and Eye Research·Manabu MochizukiKoju Kamoi
Dec 1, 1993·Arquivos de neuro-psiquiatria·I LessaA Melo
Jun 1, 1989·Arquivos de neuro-psiquiatria·C M CostaA M De Arruda
Dec 1, 1995·Arquivos de neuro-psiquiatria·M Menna-BarretoO Bianchini
Jun 1, 1992·Virology·A Caputo, W A Haseltine
Jan 1, 1995·Neurology·Y KurodaF Mihara
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·E TouzéO Gout
Oct 27, 2018·JBJS Reviews·Anthony KouriMustafa Khan
Jan 1, 1990·Annals of the New York Academy of Sciences·J E Merrill
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·P Rodgers-JohnsonD C Gajdusek
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Joseph R Berger
Mar 18, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mirna M BiglioneMaria I Berría
Nov 1, 1987·Annals of Neurology·I MiyaiN Hirono
Sep 1, 1989·Annals of Neurology·M YoshidaS Sonoda
Feb 15, 1989·International Journal of Cancer. Journal International Du Cancer·A GessainJ Périès
Jan 1, 1988·Autoimmunity·I KitajimaA Igata
Sep 27, 2005·Brain : a Journal of Neurology·P CabreD Smadja
Aug 9, 2019·Scientific Reports·Beatriz Helena B VasconcelosGivago S Souza
Jun 18, 1998·Arquivos de neuro-psiquiatria·A C FerrazR G Nogueira
Jan 17, 1995·International Journal of Cancer. Journal International Du Cancer·L Morand-JoubertJ J Lefrere
Dec 13, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Lucinda A SouzaAntonio Carlos R Vallinoto
Jan 1, 1988·Annals of Neurology·P Rodgers-JohnsonD C Gajdusek
Mar 1, 1996·Arquivos de neuro-psiquiatria·C M De Castro-Costa
Aug 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C PowerG P Rice
Jan 1, 1988·Annals of Neurology·R T JohnsonA Vaisberg
May 26, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ariella L G Coler-ReillyYoshihisa Yamano
Jul 5, 1993·The Medical Journal of Australia·N RajabalendaranP Lindschau

Related Concepts

Antibodies, Viral
HIV
Spastic
Todd Paralysis
Study of Serum
Deltaretrovirus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.